Daoust M, Compagnon P, Legrand E, Boucly P
Pharmacochimie, U.F.R. de Medecine et Pharmacie, Saint Etienne du Rouvray, France.
Life Sci. 1991;48(20):1969-76. doi: 10.1016/0024-3205(91)90230-9.
Ethanol intake and synaptosomal 3H-serotonin uptake were studied in male Fawn-Hooded and Sprague-Dawley rats. Fawn-Hooded rats consumed more alcohol and more water than Sprague-Dawley rats. Plasma alcohol levels of Sprague-Dawley rats were not detectable but were about 5 mg/dl in Fawn-Hooded rats. Ethanol intake increased the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex, but not in thalamus. In Fawn-Hooded rats, serotonin uptake (Vmax) was higher than in Sprague-Dawley rats cortex. Ethanol intake reduced the Vmax of serotonin uptake in Fawn-Hooded rats in hippocampus and cortex. In cortex, the carrier affinity for serotonin was increased in alcoholized Fawn-Hooded rats. These results indicate that synaptosomal 3H-serotonin uptake is affected by ethanol intake. In Fawn-Hooded rats, high ethanol consumption is associated with high serotonin uptake. In rats presenting high serotonin uptake, alcoholisation reduces 3H-serotonin internalisation in synaptosomes, indicating a specific sensitivity to alcohol intake of serotonin uptake system.
对雄性花斑豚鼠和斯普拉格-道利大鼠的乙醇摄入量和突触体3H-血清素摄取进行了研究。花斑豚鼠比斯普拉格-道利大鼠摄入更多的酒精和水。斯普拉格-道利大鼠的血浆酒精水平检测不到，但花斑豚鼠的血浆酒精水平约为5mg/dl。乙醇摄入增加了花斑豚鼠海马体和皮质中血清素摄取的最大速度（Vmax），但丘脑没有变化。在花斑豚鼠中，血清素摄取（Vmax）高于斯普拉格-道利大鼠的皮质。乙醇摄入降低了花斑豚鼠海马体和皮质中血清素摄取的Vmax。在皮质中，酒精化的花斑豚鼠对血清素的载体亲和力增加。这些结果表明，突触体3H-血清素摄取受乙醇摄入的影响。在花斑豚鼠中，高乙醇消耗量与高血清素摄取有关。在血清素摄取高的大鼠中，酒精化会降低突触体中3H-血清素的内化，表明血清素摄取系统对酒精摄入具有特定敏感性。
