Nachmias V T
Department of Cell and Developmental Biology, University of Pennsylvania Medical School, Philadelphia 19104-6058.
Curr Opin Cell Biol. 1993 Feb;5(1):56-62. doi: 10.1016/s0955-0674(05)80008-0.
Thymosin beta 4 is a major actin monomer binding protein present at high concentration in many vertebrate cells and cell lines. The interactions of actin with thymosin beta 4, actobindin and profilin are compared. Nine beta-thymosins have been identified; six have been shown to bind to actin. Regulation of the synthesis of thymosin beta 10 and thymosin beta 4 has been found in brain development and after stimulation of several cell types, respectively. The extracellular effects of thymosin beta 4 still need clarification.
胸腺素β4是一种主要的肌动蛋白单体结合蛋白，在许多脊椎动物细胞和细胞系中高浓度存在。对肌动蛋白与胸腺素β4、肌动蛋白结合蛋白和原肌球蛋白的相互作用进行了比较。已鉴定出9种β-胸腺素；其中6种已被证明能与肌动蛋白结合。分别在大脑发育过程和几种细胞类型受到刺激后发现了胸腺素β10和胸腺素β4合成的调节。胸腺素β4的细胞外作用仍需阐明。
