非胰岛素依赖型糖尿病患者对乙酰氨基酚的消除情况。
Paracetamol elimination in patients with non-insulin dependent diabetes mellitus.
作者信息
Kamali F, Thomas S H, Ferner R E
机构信息
Wolfson Unit of Clinical Pharmacology, University of Newcastle upon Tyne.
出版信息
Br J Clin Pharmacol. 1993 Jan;35(1):58-61. doi: 10.1111/j.1365-2125.1993.tb05672.x.
Abstract
The pharmacokinetics and metabolism of an intravenous dose (500 mg) of paracetamol were studied in a group of non-insulin dependent diabetic patients (n = 10) and in a group of healthy control subjects (n = 9). Paracetamol clearance, half-life and the partial clearance to paracetamol glucuronide were not significantly different, but the partial clearance to paracetamol sulphate was significantly reduced (62 +/- 18 vs 86 +/- 17 ml h-1 kg-1 (mean +/- s.d.)) and the renal clearance of paracetamol was significantly increased (56 +/- 20 vs 22 +/- 6 ml h-1 kg-1 (mean +/- s.d.)) in the non-insulin dependent diabetic patients, compared with the control group.
摘要
在一组非胰岛素依赖型糖尿病患者（n = 10）和一组健康对照受试者（n = 9）中研究了静脉注射一剂（500 mg）对乙酰氨基酚的药代动力学和代谢情况。对乙酰氨基酚的清除率、半衰期以及向对乙酰氨基酚葡萄糖醛酸苷的部分清除率无显著差异，但与对照组相比，非胰岛素依赖型糖尿病患者向对乙酰氨基酚硫酸盐的部分清除率显著降低（62±18对86±17 ml h-1 kg-1（平均值±标准差）），且对乙酰氨基酚的肾清除率显著增加（56±20对22±6 ml h-1 kg-1（平均值±标准差））。
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