Michals D R, Smith H E
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235.
Chirality. 1993;5(1):20-3. doi: 10.1002/chir.530050105.
The absolute configuration of (+)-cis-2,3-dihydro-2[(methylamino)methyl]- 1-[4-(trifluoromethyl)phenoxy]-1H-indene hydrochloride, the more active enantiomer of a new serotonin inhibitor, was established as 1S,2S. This assignment was based on the application of the benzene sector and chirality rules to the interpretation of the inhibitor's circular dichroism spectrum and the spectra of other related chiral 1-substituted 2,3-dihydro-1H-indenes.
新型血清素抑制剂活性较高的对映体（+）-顺式-2,3-二氢-2-[(甲氨基)甲基]-1-[4-(三氟甲基)苯氧基]-1H-茚盐酸盐的绝对构型确定为1S,2S。该构型归属是基于应用苯扇区规则和手性规则来解释该抑制剂的圆二色光谱以及其他相关手性1-取代2,3-二氢-1H-茚的光谱。
