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碘化β-甲基支链脂肪酸类似物[125I](对碘苯基)-3-(R,S)-甲基十五烷酸（BMIPP）在心肌中的蓄积及其与三磷酸腺苷（ATP）浓度的相关性——II. 盐诱导高血压大鼠的研究

Myocardial accumulation of iodinated beta-methyl-branched fatty acid analog, [125I](p-iodophenyl)-3-(R,S)-methylpentadecanoic acid (BMIPP), and correlation to ATP concentration--II. Studies in salt-induced hypertensive rats.

作者信息

Fujibayashi Y, Som P, Yonekura Y, Knapp F F, Tamaki N, Yamamoto K, Konishi J, Yokoyama A

机构信息

Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

出版信息

Nucl Med Biol. 1993 Feb;20(2):163-6. doi: 10.1016/0969-8051(93)90109-8.

DOI:10.1016/0969-8051(93)90109-8
PMID:8448569
Abstract

This study investigates the possible relationship between myocardial [125I]BMIPP accumulation and ATP concentration, in the salt-induced hypertensive Dahl-strain rats. [125I]BMIPP accumulation in the myocardium was inversely related to the degree of hypertension. On the other hand, ATP levels increased in the myocardium of rats with higher blood pressure showing an inverse relationship with BMIPP accumulation. Further studies are required for elucidating these possible inter-related phenomena.

摘要

本研究调查了盐诱导的高血压 Dahl 品系大鼠心肌中[125I]BMIPP 蓄积与 ATP 浓度之间的可能关系。心肌中[125I]BMIPP 的蓄积与高血压程度呈负相关。另一方面，血压较高的大鼠心肌中的 ATP 水平升高，与 BMIPP 蓄积呈负相关。需要进一步研究以阐明这些可能相互关联的现象。

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