Hitzeroth H W, Bender K, Ropers H H, Geerthsen J M
Hum Genet. 1977 Feb 11;35(2):175-83. doi: 10.1007/BF00393967.
Blood specimens from a random sample of 981 South African Negroid females were typed electrophoretically inter alia for their G-6-PD phenotypes, The allele frequency for GdB and GdnonB was found to be 0.8126 and 0.1874 respectively. Calculating the number of individuals expected for each phenotypic class, a highly significant deviation from the Hardy-Weinberg equilibrium became manifest, i.e. there was a deficit of 24.6% of heterozygotes and an excess of 12.3% of each of the two classes of homozygotes. Several possible reasons for this discrepancy e.g. the effects of pooling sub-samples, selection and misclassifications due to insufficient staining were examined and were found not be likely explanations for the observed phenomenon. Instead, the result is interpreted as due to only 3--4 stem cells which give rise to the haematopoetic system in man.
从981名南非黑人女性的随机样本中采集血液标本，用电泳法对其G-6-PD表型等进行分型。发现GdB和GdnonB的等位基因频率分别为0.8126和0.1874。计算每个表型类别的预期个体数，发现与哈迪-温伯格平衡存在高度显著偏差，即杂合子短缺24.6%，两类纯合子各过量12.3%。研究了造成这种差异的几个可能原因，如合并子样本的影响、选择以及因染色不足导致的错误分类，但发现这些都不太可能是观察到的现象的解释。相反，该结果被解释为仅由3 - 4个产生人类造血系统的干细胞所致。
