用瘤内注射长春碱治疗口腔卡波西肉瘤。
Treatment of oral Kaposi sarcoma with intralesional vinblastine.
作者信息
Epstein J B
机构信息
Division of Dentistry, British Columbia Cancer Agency, Vancouver.
出版信息
Cancer. 1993 Mar 1;71(5):1722-5. doi: 10.1002/1097-0142(19930301)71:5<1722::aid-cncr2820710503>3.0.co;2-0.
BACKGROUND
Kaposi sarcoma (KS) is an acquired immune deficiency syndrome-defining condition in human immunodeficiency virus infection. Oral KS may produce local symptoms and require treatment. Palliation of oral lesions may be achieved with radiation therapy and chemotherapy. This review was conducted to assess the effect of intralesional vinblastine in the management of oral KS.
METHODS
Patients were referred because of oral KS. Intralesional injection of vinblastine (0.2 mg/ml) was conducted under local anesthesia, and patients were observed to determine the effect of treatment.
RESULTS
Forty-two patients with oral KS were treated with intralesional vinblastine. A greater than 50% reduction in the lesions was seen in 74% of patients. The mean duration of response was 3.52 months for all patients. For patients not lost to follow-up and observed until recurrence of the oral lesions, palliation was achieved for a mean of 4.25 months.
CONCLUSIONS
Effective local palliation of oral KS can be achieved with intralesional injection of vinblastine.
背景
卡波西肉瘤（KS）是人类免疫缺陷病毒感染中获得性免疫缺陷综合征的定义性疾病。口腔KS可能产生局部症状并需要治疗。放射治疗和化疗可缓解口腔病变。本综述旨在评估病灶内注射长春碱治疗口腔KS的效果。
方法
患者因口腔KS前来就诊。在局部麻醉下进行病灶内注射长春碱（0.2mg/ml），并观察患者以确定治疗效果。
结果
42例口腔KS患者接受了病灶内注射长春碱治疗。74%的患者病灶缩小超过50%。所有患者的平均缓解持续时间为3.52个月。对于未失访且观察至口腔病变复发的患者，平均缓解时间为4.25个月。
结论
病灶内注射长春碱可有效局部缓解口腔KS。
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