Gentil B, Paugam C, Wolf C, Lienhart A, Augereau B
Saint Antoine Hospital, Paris, France.
Clin Orthop Relat Res. 1993 Feb(287):112-6.
Methylmethacrylate (MMA) plasma concentrations were measured in 11 patients scheduled for total hip arthroplasty. After acetabular and after femoral cement implantation, sequential blood samples were withdrawn from pulmonary and radial artery catheters. The peak concentration of MMA (mean +/- standard error of the mean) in pulmonary artery blood occurred two minutes after cement implantation and was significantly higher after acetabulum (5.0 +/- 1.3 micrograms/ml) than after femoral cement insertion (1.9 +/- 0.6 micrograms/ml). The MMA peak in plasma was above 1 micrograms/ml in 13 cases, and the decrease fit a biexponential decay (r = 0.91). The initial half-life was 0.3 +/- 0.1 minutes, and the terminal half-life was 3 +/- 0.7 minutes. The areas under the curve (AUC) were determined for pulmonary (AUCpa) and radial (AUCra) plasma samples, and the ratio (AUCpa - AUCra)/AUCpa was computed: 55.1 +/- 7.8% of MMA was cleared during the transpulmonary passage. These results demonstrate that: (1) MMA could be determined after each cement implantation, (2) MMA plasma concentrations were higher after acetabulum than after femoral cement implantation, and (3) the half-life is short and the total pulmonary clearance is high.
对11例计划行全髋关节置换术的患者测定了甲基丙烯酸甲酯（MMA）的血浆浓度。在髋臼和股骨植入骨水泥后，依次从肺动脉和桡动脉导管采集血样。肺动脉血中MMA的峰值浓度（均值±均值标准误差）在骨水泥植入后两分钟出现，髋臼植入后（5.0±1.3微克/毫升）明显高于股骨植入骨水泥后（1.9±0.6微克/毫升）。13例患者血浆中MMA峰值高于1微克/毫升，其下降符合双指数衰减（r = 0.91）。初始半衰期为0.3±0.1分钟，终末半衰期为3±0.7分钟。测定了肺动脉（AUCpa）和桡动脉（AUCra）血浆样本的曲线下面积（AUC），并计算了比值（AUCpa - AUCra）/AUCpa：55.1±7.8%的MMA在经肺过程中被清除。这些结果表明：（1）每次骨水泥植入后均可测定MMA；（2）髋臼植入后MMA血浆浓度高于股骨植入骨水泥后；（3）半衰期短，肺总清除率高。
