Kim K J, Rubash H E, Wilson S C, D'Antonio J A, McClain E J
Ferguson Laboratory, Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania.
Clin Orthop Relat Res. 1993 Feb(287):142-52.
Thirty-four membranes from 20 cementless and 14 cemented prostheses from 33 patients excised during revision arthroplasty were analyzed for foreign-body reactive processes. As a control, identical analyses were performed using adjacent pseudocapsular tissue taken from 12 patients during revision arthroplasty. Histologically, cementless membranes tended to contain more metal debris, and cemented membranes contained more foreign-body giant cells. Collagenase, gelatinase, prostaglandin E2, and interleukin-1 were measured in conditioned media taken from organ cultures of each interface membrane. Both cementless and cemented membranes released significant levels of gelatinase and collagenase, prostaglandin E2, and interleukin-1 into the conditioned media when compared with control tissues. However, the tissue concentrations were not significantly different between cementless and cemented membranes. Although histologic differences between cementless and cemented interface membranes exist, both share a similar capacity to release bioactive products that can induce bone resorption and cause aseptic loosening of the hip prostheses.
对33例患者翻修关节成形术期间切除的20个非骨水泥假体和14个骨水泥假体的34层包膜进行了异物反应过程分析。作为对照，在翻修关节成形术期间，使用取自12例患者的相邻假包膜组织进行了相同的分析。组织学上，非骨水泥包膜倾向于含有更多的金属碎屑，而骨水泥包膜含有更多的异物巨细胞。在取自每个界面膜器官培养物的条件培养基中测量胶原酶、明胶酶、前列腺素E2和白细胞介素-1。与对照组织相比，非骨水泥和骨水泥包膜均向条件培养基中释放了显著水平的明胶酶、胶原酶、前列腺素E2和白细胞介素-1。然而，非骨水泥和骨水泥包膜之间的组织浓度没有显著差异。尽管非骨水泥和骨水泥界面膜之间存在组织学差异，但两者释放可诱导骨吸收并导致髋关节假体无菌性松动的生物活性产物的能力相似。
