豚鼠中过氧化氢清除酶的种属差异，特别提及谷胱甘肽过氧化物酶

Species difference in hydroperoxide-scavenging enzymes with special reference to glutathione peroxidase in guinea-pigs.

Himeno S, Takekawa A, Imura N

Kitasato University, School of Pharmaceutical Sciences, Tokyo, Japan.

Comp Biochem Physiol B. 1993 Jan;104(1):27-31. doi: 10.1016/0305-0491(93)90334-2.

Abstract

As guinea-pigs have been reported to have a markedly low activity of glutathione peroxidase (GSH-Px), the activity of other hydroperoxide-scavenging enzymes was investigated. 2. Catalase activity in guinea-pig tissues was 2-3 times higher than that of mice or rats. 3. Approximately 90% of catalase activity was found in the soluble fraction of guinea-pig liver, suggesting a compensatory role of catalase in removing H2O2 in the cytosol of guinea-pig tissues. 4. In erythrocytes, GSH-Px activity does not differ among rodents. This may reflect the fact that GSH-Px is the sole enzyme in the removal of organic hydroperoxides in erythrocytes where glutathione S-transferase activity is barely detectable.

摘要

由于据报道豚鼠的谷胱甘肽过氧化物酶（GSH-Px）活性明显较低，因此对其他氢过氧化物清除酶的活性进行了研究。2. 豚鼠组织中的过氧化氢酶活性比小鼠或大鼠高2至3倍。3. 在豚鼠肝脏的可溶性部分中发现约90%的过氧化氢酶活性，这表明过氧化氢酶在清除豚鼠组织细胞质中的H2O2方面具有补偿作用。4. 在红细胞中，啮齿动物的GSH-Px活性没有差异。这可能反映了这样一个事实，即GSH-Px是红细胞中清除有机氢过氧化物的唯一酶，而在红细胞中谷胱甘肽S-转移酶活性几乎检测不到。