通过荧光原位杂交技术，分别将KREV1转化抑制基因及其假基因（KREV1P）定位到人类染色体1p13.3和14q24.3上。
Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13.3 and 14q24.3, respectively, by fluorescence in situ hybridization.
作者信息
Takai S, Nishino N, Kitayama H, Ikawa Y, Noda M
机构信息
Department of Viral Oncology, Cancer Institute, Tokyo, Japan.
出版信息
Cytogenet Cell Genet. 1993;63(1):59-61. doi: 10.1159/000133503.
The chromosomal location of the transformation suppressor gene KREV1 and its pseudogene (KREV1P) on R-banded human prometaphase chromosomes was determined by fluorescence in situ hybridization. The KREV1 gene mapped to chromosome 1p13.3, whereas the KREV1P pseudogene mapped to 14q24.3. Our results substantiate the previous mapping data of Rousseau-Merck et al. (1990) and further confine the position of the RAP1A/KREV1 gene to a narrower region.
通过荧光原位杂交确定了转化抑制基因KREV1及其假基因（KREV1P）在R带人类早中期染色体上的染色体定位。KREV1基因定位于1号染色体的1p13.3，而KREV1P假基因定位于14号染色体的14q24.3。我们的结果证实了Rousseau-Merck等人（1990年）先前的定位数据，并进一步将RAP1A/KREV1基因的位置限定在一个更窄的区域。
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