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Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization.

作者信息

Takai S, Tanaka M, Sugimura H, Yamada K, Naito Y, Kino I, Matsuda M

机构信息

Department of Genetics, Research Institute, International Medical Center, Tokyo, Japan.

出版信息

Hum Genet. 1994 Nov;94(5):549-50. doi: 10.1007/BF00211024.

DOI:10.1007/BF00211024
PMID:7959692
Abstract

C3G, a human guanine nucleotide releasing protein for Ras protein, was mapped to human chromosome 9q34.3 by fluorescence in situ hybridization with R-banded chromosomes. C3G was originally identified as one of the CRK-binding proteins, similar to c-abl (9q34.1). Our result suggests that the downstream factors of Crk are localized in close proximity on chromosome 9.

摘要

相似文献

1
Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ hybridization.
Hum Genet. 1994 Nov;94(5):549-50. doi: 10.1007/BF00211024.
2
Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers.C3G（CRK SH3结构域结合鸟嘌呤核苷酸释放因子）在非小细胞肺癌中的扩增、上调和过表达。
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3
Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene.将Ras-GRF2基因（GRF2）定位到小鼠13号染色体C3-D1区域以及人类5号染色体q13区域，靠近Ras-GAP基因。
Genomics. 1997 Jan 1;39(1):118-20. doi: 10.1006/geno.1996.4484.
4
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.C3G是一种普遍表达的鸟嘌呤核苷酸释放蛋白，它与CRK以及GRB2/ASH蛋白的Src同源3结构域结合。
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3443-7. doi: 10.1073/pnas.91.8.3443.
5
Activation of the Drosophila C3G leads to cell fate changes and overproliferation during development, mediated by the RAS-MAPK pathway and RAP1.果蝇C3G的激活会在发育过程中导致细胞命运改变和过度增殖，这是由RAS-MAPK途径和RAP1介导的。
EMBO J. 1999 Jan 4;18(1):145-55. doi: 10.1093/emboj/18.1.145.
6
Transformation suppressor activity of C3G is independent of its CDC25-homology domain.C3G的转化抑制活性不依赖于其CDC25同源结构域。
Oncogene. 1998 Feb 5;16(5):613-24. doi: 10.1038/sj.onc.1201569.
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Identification of a human guanine nucleotide-releasing factor (H-GRF55) specific for Ras proteins.一种对Ras蛋白具有特异性的人类鸟嘌呤核苷酸释放因子（H-GRF55）的鉴定。
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[Activation of Rap1, antagonist to ras, by Crk-C3G].[Crk-C3G对Ras的拮抗剂Rap1的激活作用]
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Genomics. 1996 Jul 15;35(2):403-4. doi: 10.1006/geno.1996.0378.
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Localization of the human dopamine beta hydroxylase (DBH) gene to chromosome 9q34.人类多巴胺β羟化酶（DBH）基因定位于9号染色体长臂34区。
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本文引用的文献

1
Molecular analysis of six variant Philadelphia chromosome translocations in chronic myeloid leukemia.慢性髓性白血病中六种变异型费城染色体易位的分子分析
Cancer Genet Cytogenet. 1993 May;67(1):50-4. doi: 10.1016/0165-4608(93)90043-l.
2
The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1.
Hum Mol Genet. 1993 Mar;2(3):237-40. doi: 10.1093/hmg/2.3.237.
3
Mapping of the KREV1 transformation suppressor gene and its pseudogene (KREV1P) to human chromosome 1p13.3 and 14q24.3, respectively, by fluorescence in situ hybridization.通过荧光原位杂交技术，分别将KREV1转化抑制基因及其假基因（KREV1P）定位到人类染色体1p13.3和14q24.3上。
原发性常染色体隐性小头畸形的第三个新基因座定位于9号染色体长臂34区。
Am J Hum Genet. 2000 Feb;66(2):724-7. doi: 10.1086/302777.
Cytogenet Cell Genet. 1993;63(1):59-61. doi: 10.1159/000133503.
4
CRK proto-oncogene maps to human chromosome band 17p13.CRK原癌基因定位于人类染色体17p13带。
Oncogene. 1993 Oct;8(10):2853-5.
5
Mapping of the human gene encoding the mutual signal-transducing subunit (beta-chain) of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and interleukin-5 (IL-5) receptor complexes to chromosome 22q13.1.
Hum Genet. 1994 Feb;93(2):198-200. doi: 10.1007/BF00210610.
6
Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites.Abl蛋白酪氨酸激酶利用SH3结合位点选择Crk衔接蛋白作为底物。
Genes Dev. 1994 Apr 1;8(7):783-95. doi: 10.1101/gad.8.7.783.
7
C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins.C3G是一种普遍表达的鸟嘌呤核苷酸释放蛋白，它与CRK以及GRB2/ASH蛋白的Src同源3结构域结合。
Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3443-7. doi: 10.1073/pnas.91.8.3443.
8
Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma line.敏感、高分辨率的染色质和染色体原位图谱：淋巴瘤细胞系中两个紧密整合的EBV拷贝的存在及方向
Cell. 1988 Jan 15;52(1):51-61. doi: 10.1016/0092-8674(88)90530-2.
9
R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1).R带和非同位素原位杂交：人类Ⅱ型胶原基因（COL2A1）的精确定位
Hum Genet. 1990 Nov;86(1):14-6. doi: 10.1007/BF00205165.
10
Mapping of the MYC gene to band 8q24.12----q24.13 by R-banding and distal to fra(8)(q24.11), FRA8E, by fluorescence in situ hybridization.通过R显带将MYC基因定位于8q24.12----q24.13带，并通过荧光原位杂交将其定位于fra(8)(q24.11)（FRA8E）的远侧。
Cytogenet Cell Genet. 1991;57(2-3):109-11. doi: 10.1159/000133124.