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Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms.

作者信息

Kumar S, White D L, Takai S, Turczynowicz S, Juttner C A, Hughes T P

机构信息

Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia.

出版信息

Hum Genet. 1995 Jun;95(6):641-4. doi: 10.1007/BF00209480.

DOI:10.1007/BF00209480
PMID:7789948
Abstract

Developmentally regulated mouse gene Nedd2 encodes a protein similar to the product of the nematode Caenorhabditis elegans cell death gene ced-3 and the mammalian interleukin-1 beta-converting enzyme. Overexpression of Nedd2 in cultured mammalian cells induces apoptosis that can be blocked by proto-oncogene BCL2. We have isolated cDNA clones for the human homologue of the mouse gene and, by using these as probes, mapped the human NEDD2 gene to 7q34-35 by fluorescence in situ hybridisation. The potential tumour suppressor function of NEDD2 is discussed.

摘要

相似文献

1
Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms.
Hum Genet. 1995 Jun;95(6):641-4. doi: 10.1007/BF00209480.
2
Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.小鼠Nedd2基因诱导细胞凋亡，该基因编码一种与秀丽隐杆线虫细胞死亡基因ced-3及哺乳动物白细胞介素-1β转化酶的产物相似的蛋白质。
Genes Dev. 1994 Jul 15;8(14):1613-26. doi: 10.1101/gad.8.14.1613.
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Characterization of a mammalian cell death gene Nedd2.一种哺乳动物细胞死亡基因Nedd2的特性分析。
Leukemia. 1997 Apr;11 Suppl 3:385-6.
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Inhibition of apoptosis by the expression of antisense Nedd2.通过反义Nedd2的表达抑制细胞凋亡。
FEBS Lett. 1995 Jul 10;368(1):69-72. doi: 10.1016/0014-5793(95)00602-6.
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Cloning and expression of the cDNA encoding rat caspase-2.编码大鼠半胱天冬酶-2的cDNA的克隆与表达
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Up-regulation of the Nedd2 gene encoding an ICE/Ced-3-like cysteine protease in the gerbil brain after transient global ischemia.
J Cereb Blood Flow Metab. 1997 May;17(5):507-14. doi: 10.1097/00004647-199705000-00004.
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Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Mch2，凋亡性Ced-3/Ice半胱氨酸蛋白酶基因家族的一个新成员。
Cancer Res. 1995 Jul 1;55(13):2737-42.
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Identification and mapping of Casp7, a cysteine protease resembling CPP32 beta, interleukin-1 beta converting enzyme, and CED-3.Casp7的鉴定与定位，Casp7是一种类似于CPP32β、白细胞介素-1β转化酶和CED-3的半胱氨酸蛋白酶。
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Expression of candidate cell death genes in cell lines during apoptosis.凋亡过程中候选细胞死亡基因在细胞系中的表达。
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10
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.秀丽隐杆线虫细胞死亡蛋白CED-3是一种半胱氨酸蛋白酶，其底物特异性与人CPP32蛋白酶相似。
Genes Dev. 1996 May 1;10(9):1073-83. doi: 10.1101/gad.10.9.1073.

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Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme.小鼠Nedd2基因诱导细胞凋亡，该基因编码一种与秀丽隐杆线虫细胞死亡基因ced-3及哺乳动物白细胞介素-1β转化酶的产物相似的蛋白质。
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