Marshall W H, Barnard J M, Buehler S K, Crumley J, Larsen B
Int J Cancer. 1977 Apr 15;19(4):450-5. doi: 10.1002/ijc.2910190403.
A familial aggregate of seven cases of Hodgkin's disease (HD) has been investigated by HLA typing. Over 600 people in the immediate population (i.e. about half) have been HLA typed and haplotypes have been obtained for 95% of them. It was expected that the cases would share a particular HLA haplotype or at least that they would have one or two HLA antigens of the same series in common. However, this was not the case so no simple idea of association of HLA with HD cases was upheld. When antigen frequencies were examined in the whole population, it was found that HLA B18 increased progressively in incidence from 0.08 to 0.4 in successive groups of individuals each one more closely related to the HD cases. Similarly the community with the highest incidence of HD also had the highest incidence of B18. Thus B18, which in the world figures carries the highest relative risk, emerged as important in this study. Of four proposed interpretations of the data, we are most interested in the idea that the important HLA association is at a population level rather than at the level of the individual patient. A hypothesis, based on the concept of a "healthy carrier" for the HD agent, explains how such an association might operate. It is possible that B18-linked complement deficiency could be the basis for such a carrier state.
通过HLA分型对7例霍奇金病（HD）的家族聚集情况进行了研究。对近600名直系亲属（即约一半）进行了HLA分型，其中95%获得了单倍型。预计这些病例会共享一种特定的HLA单倍型，或者至少会有一两种同一系列的HLA抗原相同。然而，实际情况并非如此，因此HLA与HD病例之间不存在简单关联的观点不成立。在对整个人群的抗原频率进行检查时发现，HLA B18在与HD病例关系越来越密切的连续几组个体中的发生率从0.08逐渐增加到0.4。同样，HD发病率最高的群体中B18的发病率也最高。因此，在全球数据中相对风险最高的B18在本研究中显得很重要。在对数据提出的四种解释中，我们最感兴趣的观点是，重要的HLA关联是在人群水平而非个体患者水平上。基于HD病原体“健康携带者”概念的一个假说是解释这种关联可能如何起作用的。与B18相关的补体缺陷可能是这种携带者状态的基础。
