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Dendroaspin: a potent integrin receptor inhibitor from the venoms of Dendroaspis viridis and D. jamesonii.

作者信息

Williams J A, Lu X, Rahman S, Keating C, Kakkar V

机构信息

Protein Biochemistry Section, Thrombosis Research Institute, Chelsea, London, England.

出版信息

Biochem Soc Trans. 1993 Feb;21(1):73S. doi: 10.1042/bst021073s.

DOI:10.1042/bst021073s
PMID:8449356
Abstract
摘要

相似文献

1
Dendroaspin: a potent integrin receptor inhibitor from the venoms of Dendroaspis viridis and D. jamesonii.
Biochem Soc Trans. 1993 Feb;21(1):73S. doi: 10.1042/bst021073s.
2
Three-dimensional structure of the RGD-containing neurotoxin homologue dendroaspin.含RGD的神经毒素同源物树眼镜蛇毒素的三维结构。
Nat Struct Biol. 1994 Nov;1(11):802-7. doi: 10.1038/nsb1194-802.
3
Arg-Tyr-Asp (RYD) and Arg-Cys-Asp (RCD) motifs in dendroaspin promote selective inhibition of beta1 and beta3 integrins.树眼镜蛇毒素中的精氨酸-酪氨酸-天冬氨酸（RYD）和精氨酸-半胱氨酸-天冬氨酸（RCD）基序可促进对β1和β3整合素的选择性抑制。
Biochem J. 2001 May 15;356(Pt 1):11-7. doi: 10.1042/0264-6021:3560011.
4
Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion.对树眼镜蛇毒素（一种血小板聚集和细胞黏附抑制剂）的RGD基序侧翼脯氨酸残基作用的评估。
Biochem J. 2001 May 1;355(Pt 3):633-8. doi: 10.1042/bj3550633.
5
The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanking the sequence RGD.整合素αIIbβ3含有与蛇毒RGD（精氨酸-甘氨酸-天冬氨酸）蛋白不同且相互作用的结合位点。有证据表明，蛇毒RGD蛋白的受体结合特性与RGD序列侧翼的氨基酸环境有关。
Biochem J. 1995 Nov 15;312 ( Pt 1)(Pt 1):223-32. doi: 10.1042/bj3120223.
6
Substitutions of proline 42 to alanine and methionine 46 to asparagine around the RGD domain of the neurotoxin dendroaspin alter its preferential antagonism to that resembling the disintegrin elegantin.在神经毒素树眼镜蛇毒素的RGD结构域周围，脯氨酸42替换为丙氨酸以及甲硫氨酸46替换为天冬酰胺，会改变其对整联蛋白抑制素elegantin的优先拮抗作用。
J Biol Chem. 1996 Jan 5;271(1):289-94. doi: 10.1074/jbc.271.1.289.
7
1H-NMR assignments and secondary structure of dendroaspin, an RGD-containing glycoprotein IIb-IIIa (alpha IIb-beta 3) antagonist with a neurotoxin fold.
Eur J Biochem. 1994 Dec 15;226(3):861-8. doi: 10.1111/j.1432-1033.1994.00861.x.
8
Amino acid sequence of a muscarinic toxin deduced from the cDNA nucleotide sequence.从cDNA核苷酸序列推导的一种毒蕈碱毒素的氨基酸序列。
Toxicon. 1991;29(4-5):516-20. doi: 10.1016/0041-0101(91)90026-n.
9
Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide RGD in determining the inhibitory properties of snake-venom RGD proteins.蛇毒RGD（精氨酸-甘氨酸-天冬氨酸）蛋白对整合素αIIbβ3与固定化糖蛋白配体相互作用的优先拮抗作用。支持三肽RGD侧翼氨基酸残基在决定蛇毒RGD蛋白抑制特性中起功能作用的证据。
Biochem J. 1994 Dec 15;304 ( Pt 3)(Pt 3):929-36. doi: 10.1042/bj3040929.
10
Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin alphaIIbbeta3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery.野生型和变体整合素αIIbβ3对表达特定精氨酸-甘氨酸-天冬氨酸（RGD）序列基序的蛇毒蛋白的差异识别：RGD配体识别的不同位点表现出负别构效应的进一步证据。
Biochem J. 2000 Feb 1;345 Pt 3(Pt 3):701-9.

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Three finger toxins of elapids: structure, function, clinical applications and its inhibitors.眼镜蛇科动物的三种神经毒素：结构、功能、临床应用及其抑制剂。
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Exogenous Integrin αIIbβ3 Inhibitors Revisited: Past, Present and Future Applications.
外源性整合素 αIIbβ3 抑制剂再探：过去、现在和未来的应用。
Int J Mol Sci. 2021 Mar 25;22(7):3366. doi: 10.3390/ijms22073366.
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Effect of P to A mutation of the N-terminal residue adjacent to the Rgd motif on rhodostomin: importance of dynamics in integrin recognition.Rgd 基序附近 N 端残基 P 到 A 突变对 rhodostomin 的影响：整合素识别中动力学的重要性。
PLoS One. 2012;7(1):e28833. doi: 10.1371/journal.pone.0028833. Epub 2012 Jan 4.
5
Crystallization and preliminary X-ray diffraction analysis of hemextin A: a unique anticoagulant protein from Hemachatus haemachatus venom.血毒素A的结晶及初步X射线衍射分析：一种来自角蝰毒液的独特抗凝血蛋白。
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):701-3. doi: 10.1107/S1744309107034239. Epub 2007 Jul 21.
6
The transcriptome of the salivary glands of the female western black-legged tick Ixodes pacificus (Acari: Ixodidae).雌性太平洋硬蜱（蜱螨目：硬蜱科）唾液腺的转录组
Insect Biochem Mol Biol. 2005 Oct;35(10):1142-61. doi: 10.1016/j.ibmb.2005.05.007.
7
Arg-Tyr-Asp (RYD) and Arg-Cys-Asp (RCD) motifs in dendroaspin promote selective inhibition of beta1 and beta3 integrins.树眼镜蛇毒素中的精氨酸-酪氨酸-天冬氨酸（RYD）和精氨酸-半胱氨酸-天冬氨酸（RCD）基序可促进对β1和β3整合素的选择性抑制。
Biochem J. 2001 May 15;356(Pt 1):11-7. doi: 10.1042/0264-6021:3560011.
8
Evaluation of the role of proline residues flanking the RGD motif of dendroaspin, an inhibitior of platelet aggregation and cell adhesion.对树眼镜蛇毒素（一种血小板聚集和细胞黏附抑制剂）的RGD基序侧翼脯氨酸残基作用的评估。
Biochem J. 2001 May 1;355(Pt 3):633-8. doi: 10.1042/bj3550633.
9
Modulation of RGD sequence motifs regulates disintegrin recognition of alphaIIb beta3 and alpha5 beta1 integrin complexes. Replacement of elegantin alanine-50 with proline, N-terminal to the RGD sequence, diminishes recognition of the alpha5 beta1 complex with restoration induced by Mn2+ cation.RGD序列基序的调节可调控去整合素对αIIbβ3和α5β1整合素复合物的识别。在RGD序列N端将elegantin的丙氨酸-50替换为脯氨酸，会减少对α5β1复合物的识别，而Mn2+阳离子可诱导恢复这种识别。
Biochem J. 1998 Oct 15;335 ( Pt 2)(Pt 2):247-57. doi: 10.1042/bj3350247.
10
Amino acid sequence and molecular modelling of glycoprotein IIb-IIIa and fibronectin receptor iso-antagonists from Trimeresurus elegans venom.竹叶青蛇毒糖蛋白IIb-IIIa和纤连蛋白受体异拮抗剂的氨基酸序列及分子建模
Biochem J. 1996 Nov 1;319 ( Pt 3)(Pt 3):775-82. doi: 10.1042/bj3190775.