8-L-高精氨酸-血管紧张素和1-脱氨基-8-L-高精氨酸-血管紧张素的固相合成及某些激素活性
Solid phase synthesis and some hormonal activities of 8-L-homoarginine-vasotocin and 1-deamino-8-L-homoarginine-vasotocin.
作者信息
Larsson L E, Lindeberg E G, Melin P
出版信息
Int J Pept Protein Res. 1977;9(3):182-6. doi: 10.1111/j.1399-3011.1977.tb03479.x.
Abstract
8-L-Homoarginine-vasotocin and its 1-deamino derivative were synthesized by the solid phase method. Both compounds possessed high activities in the uterus contraction and fowl depressor assays and showed higher pressor activities than the corresponding vasopressins. Homoarginine-vasotocin, unexpectedly, was a more potent antidiuretic agent than its deamino analogue.
摘要
8-L-高精氨酸-催产素及其1-脱氨基衍生物通过固相法合成。这两种化合物在子宫收缩和禽类降压试验中均具有高活性，且其升压活性高于相应的加压素。出乎意料的是，高精氨酸-催产素是一种比其脱氨基类似物更强效的抗利尿剂。
Zotero 插件