Yamada Y, Stoffel M, Espinosa R, Xiang K S, Seino M, Seino S, Le Beau M M, Bell G I
Howard Hughes Medical Institute, University of Chicago, Illinois 60637.
Genomics. 1993 Feb;15(2):449-52. doi: 10.1006/geno.1993.1088.
The genes encoding three different human somatostatin receptor subtypes, designated SSTR1, SSTR2, and SSTR3, were mapped to chromosomes 14, 17, and 22, respectively, by analyzing their segregation in a panel of reduced human-hamster somatic cell hybrids. These assignments were confirmed independently using fluorescence in situ hybridization to metaphase chromosomes and the genes were further localized to 14q13, 17q24, and 22q13.1, respectively. Highly informative simple tandem repeat DNA polymorphisms were identified in SSTR1 and SSTR2.
通过分析一组减少的人-仓鼠体细胞杂种中的分离情况，将编码三种不同人类生长抑素受体亚型（分别命名为SSTR1、SSTR2和SSTR3）的基因分别定位到14号、17号和22号染色体上。使用荧光原位杂交技术对中期染色体进行检测，独立证实了这些定位，并且这些基因进一步分别定位到14q13、17q24和22q13.1。在SSTR1和SSTR2中鉴定出了信息丰富的简单串联重复DNA多态性。
