生长抑素
Somatostatin.
作者信息
Reisine T
机构信息
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
出版信息
Cell Mol Neurobiol. 1995 Dec;15(6):597-614. doi: 10.1007/BF02071127.
Abstract
- Somatostatin (SRIF) exerts diverse physiological actions in the body including regulation of hormone and neurotransmitter release and neuronal firing activity. Analogs of SRIF are used clinically to treat tumors and cancers and to block the hypersecretion of growth hormone in acromegaly. 2. The recent cloning of five SRIF receptor subtypes has allowed for the identification of the molecular basis of the cellular actions of SRIF. The ligand binding domains and regions involved in coupling to G proteins and cellular effector systems are being identified and the processes by which SRIF inhibits cell growth and proliferation are being established. Furthermore, subtype selective agonists have been generated which are being used to investigate the specific biological roles of each SRIF receptor subtypes. 3. Such information will be useful in developing a new generation of SRIF drugs that could be employed to treat metabolic diseases, disorders of the gut, cancer and abnormalities in the central nervous system such as epilepsy and Alzheimer's disease.
摘要
- 生长抑素（SRIF）在体内发挥多种生理作用，包括调节激素和神经递质的释放以及神经元的放电活动。SRIF类似物在临床上用于治疗肿瘤和癌症，并阻断肢端肥大症中生长激素的过度分泌。2. 最近克隆出五种SRIF受体亚型，这使得确定SRIF细胞作用的分子基础成为可能。正在确定与G蛋白和细胞效应系统偶联的配体结合结构域和区域，并且正在建立SRIF抑制细胞生长和增殖的过程。此外，已经产生了亚型选择性激动剂，用于研究每种SRIF受体亚型的特定生物学作用。3. 这些信息将有助于开发新一代的SRIF药物，可用于治疗代谢性疾病、肠道疾病、癌症以及中枢神经系统异常，如癫痫和阿尔茨海默病。
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