Sanderson P J
Edgware General Hospital, Middlesex, UK.
J Antimicrob Chemother. 1993 Feb;31 Suppl B:1-9. doi: 10.1093/jac/31.suppl_b.1.
Various aspects of prophylaxis in surgery are discussed. The timing of antibiotic doses is analysed in relation to the Burke laboratory model and the lag-phase of bacterial growth. Areas where further data is required: the effect of locally applied antibiotics, protection against sources of organisms and new approaches to prophylaxis are discussed. The ecological effects of antibiotics are described in relation to prophylaxis.
本文讨论了手术预防的各个方面。根据伯克实验室模型和细菌生长的延迟期分析了抗生素给药的时间。需要进一步数据的领域：讨论了局部应用抗生素的效果、针对生物体来源的防护以及预防的新方法。还描述了抗生素与预防相关的生态效应。
