Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow.
作者信息
Selig C, Nothdurft W, Fliedner T M
机构信息
Institute of Occupational and Social Medicine, University of Ulm, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1993;119(6):346-9. doi: 10.1007/BF01208843.
Abstract
N-Acetylcysteine, known as a radical scavenger, was examined for its influence on the radiotolerance of progenitor cells of granulocytopoiesis. Added before and after irradiation in a dose of 2 mg/ml to suspension cultures of non-adherent low-density human bone marrow cells N-acetylcysteine (AcCys) clearly improved the survival. The D0 value of the survival curve for granulocyte/macrophage colony-forming cells increased by a factor of 1.56 as compared to non-treated control suspensions. The improvement of radiation tolerance is probably not only based on the radical scavenger properties (radioprotective component) of AcCys, but also on the support of repair processes.
摘要
相似文献
1
Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow.
J Cancer Res Clin Oncol. 1993;119(6):346-9. doi: 10.1007/BF01208843.
2
3
Influence of different radioprotective compounds on radiotolerance and cell cycle distribution of human progenitor cells of granulocytopoiesis in vitro.
Br J Haematol. 2002 Oct;119(1):244-54. doi: 10.1046/j.1365-2141.2002.03795.x.
4
Radioprotective effects of combination broncho-vaxom, a macrophage activator, and indomethacin, an inhibitor of prostaglandin production: relationship to myelopoiesis.
Eur J Haematol. 1996 Jan-Feb;56(1-2):54-61. doi: 10.1111/j.1600-0609.1996.tb00294.x.
5
Granulocyte colony-stimulating factor with or without stem or progenitor cell or growth factors infusion for people with compensated or decompensated advanced chronic liver disease.
Cochrane Database Syst Rev. 2023 Jun 6;6(6):CD013532. doi: 10.1002/14651858.CD013532.pub2.
6
Calcium supplementation commencing before or early in pregnancy, or food fortification with calcium, for preventing hypertensive disorders of pregnancy.
Cochrane Database Syst Rev. 2017 Sep 26;9(9):CD011192. doi: 10.1002/14651858.CD011192.pub2.
7
Granulocyte and granulocyte-macrophage colony stimulating factors for newly diagnosed patients with myelodysplastic syndromes.
Cochrane Database Syst Rev. 2016 Feb 16;2(2):CD009310. doi: 10.1002/14651858.CD009310.pub2.
8
Hyperthermia, radiation carcinogenesis and the protective potential of vitamin A and N-acetylcysteine.
J Cancer Res Clin Oncol. 1996;122(6):343-50. doi: 10.1007/BF01220801.
9
Effects of recombinant growth factors on radiation survival of human bone marrow progenitor cells.
Int J Radiat Oncol Biol Phys. 1989 Feb;16(2):415-35. doi: 10.1016/0360-3016(89)90338-6.
10
Thrombopoietin mimetic stimulates bone marrow vascular and stromal niches to mitigate acute radiation syndrome.
Stem Cell Res Ther. 2024 Apr 29;15(1):123. doi: 10.1186/s13287-024-03734-z.
引用本文的文献
1
Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine.
J Radiat Res. 2016 Jun;57(3):312-7. doi: 10.1093/jrr/rrw001. Epub 2016 Mar 6.
本文引用的文献
1
The effect of N-acetylcysteine inhalation on the tolerance to thoracic radiation in mice.
Radiother Oncol. 1986 Sep;7(1):77-80. doi: 10.1016/s0167-8140(86)80126-8.
2
The radioprotective effect of N-acetylcysteine in thorax irradiation of mice.
Radiother Oncol. 1987 Sep;10(1):67-9. doi: 10.1016/s0167-8140(87)80071-3.
3
Cell cycle redistribution of cultured cells after treatment with chemical radiation protectors.
Cell Tissue Kinet. 1988 May;21(3):193-200. doi: 10.1111/j.1365-2184.1988.tb00857.x.
4
Acetylcysteine: a drug that is much more than a mucokinetic.
Biomed Pharmacother. 1988;42(8):513-9.
5
Comparative behavioral toxicity of four sulfhydryl radioprotective compounds in mice: WR-2721, cysteamine, diethyldithiocarbamate, and N-acetylcysteine.
Pharmacol Ther. 1988;39(1-3):97-100. doi: 10.1016/0163-7258(88)90046-0.
6
Clinical trials of WR-2721 prior to alkylating agent chemotherapy and radiotherapy.
Pharmacol Ther. 1988;39(1-3):3-7. doi: 10.1016/0163-7258(88)90032-0.
7
Protection of mouse bone marrow by WR-2721 after fractionated irradiation.
Int J Radiat Oncol Biol Phys. 1988 Aug;15(2):377-82. doi: 10.1016/s0360-3016(98)90019-0.
8
Effect of N-acetylcysteine on plasma cysteine and glutathione following paracetamol administration.
Eur J Clin Pharmacol. 1989;36(2):127-31. doi: 10.1007/BF00609183.
9
Effects of N-acetylcysteine on human polymorphonuclear leukocytes.
APMIS. 1989 Feb;97(2):115-9. doi: 10.1111/j.1699-0463.1989.tb00764.x.
10
2-Mercaptoethanol and n-acetylcysteine enhance T cell colony formation in AIDS and ARC.
Clin Exp Immunol. 1989 Jul;77(1):7-10.
Zotero 插件