N-乙酰半胱氨酸对人骨髓粒系/巨噬系集落形成细胞的辐射防护作用
Radioprotective effect of N-acetylcysteine on granulocyte/macrophage colony-forming cells of human bone marrow.
作者信息
Selig C, Nothdurft W, Fliedner T M
机构信息
Institute of Occupational and Social Medicine, University of Ulm, Federal Republic of Germany.
出版信息
J Cancer Res Clin Oncol. 1993;119(6):346-9. doi: 10.1007/BF01208843.
Abstract
N-Acetylcysteine, known as a radical scavenger, was examined for its influence on the radiotolerance of progenitor cells of granulocytopoiesis. Added before and after irradiation in a dose of 2 mg/ml to suspension cultures of non-adherent low-density human bone marrow cells N-acetylcysteine (AcCys) clearly improved the survival. The D0 value of the survival curve for granulocyte/macrophage colony-forming cells increased by a factor of 1.56 as compared to non-treated control suspensions. The improvement of radiation tolerance is probably not only based on the radical scavenger properties (radioprotective component) of AcCys, but also on the support of repair processes.
摘要
N-乙酰半胱氨酸作为一种自由基清除剂，已被研究其对粒细胞生成祖细胞辐射耐受性的影响。在照射前后，以2mg/ml的剂量添加到非贴壁低密度人骨髓细胞的悬浮培养物中，N-乙酰半胱氨酸（AcCys）明显提高了细胞存活率。与未处理的对照悬浮液相比，粒细胞/巨噬细胞集落形成细胞存活曲线的D0值增加了1.56倍。辐射耐受性的提高可能不仅基于AcCys的自由基清除特性（辐射防护成分），还基于对修复过程的支持。
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