液相色谱-质谱法测定血浆中的美托咪定及其他麻醉剂。
Liquid chromatography-mass spectrometry for the determination of medetomidine and other anaesthetics in plasma.
作者信息
Kanazawa H, Nagata Y, Matsushima Y, Takai N, Uchiyama H, Nishimura R, Takeuchi A
机构信息
Kyoritsu College of Pharmacy, Tokyo, Japan.
出版信息
J Chromatogr. 1993 Feb 12;631(1-2):215-20. doi: 10.1016/0021-9673(93)80524-c.
A liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric method is presented for the simultaneous determination of medetomidine and other anaesthetic drugs in solutions and dog plasma. The drugs examined were flumazenil, butorphanol, atropine, ketamine, xylazine, medetomidine, atipamezole and midazolam. The separation was carried out on a reversed-phase column using methanol-0.1 M ammonium acetate (3:2) as eluent.
本文提出了一种液相色谱 - 大气压化学电离质谱法，用于同时测定溶液和犬血浆中的美托咪定及其他麻醉药物。所检测的药物有氟马西尼、布托啡诺、阿托品、氯胺酮、赛拉嗪、美托咪定、阿替美唑和咪达唑仑。分离在反相柱上进行，以甲醇 - 0.1M 醋酸铵（3:2）作为洗脱液。
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