Coodley G O, Nelson H D, Loveless M O, Folk C
Division of Internal Medicine, Oregon Health Sciences University, Portland 97201-3098.
J Acquir Immune Defic Syndr (1988). 1993 Mar;6(3):272-6.
beta-Carotene has been reported to have an immunostimulatory effect. Recent studies suggest that beta-carotene supplementation can increase CD4 counts in HIV-infected patients. Our double-blind, placebo-controlled clinical trial was designed to test the efficacy of beta-carotene in raising CD4 counts in HIV-infected patients. Twenty-one HIV-seropositive patients were randomized to receive either beta-carotene, 180 mg/day or placebo for 4 weeks, and then crossed over to receive the alternative treatment for the following 4 weeks. beta-Carotene resulted in a statistically significant increase in total WBC count (p = 0.01), % change in CD4 count (p = 0.02), and % change in CD4/CD8 ratios (p = 0.02) compared to placebo. The absolute CD4 count, absolute CD4/CD8 ratio, and total and B-lymphocytes all increased on carotene and fell during placebo, but these differences did not reach statistical significance. No toxicity was observed on either treatment. beta-Carotene appears to have an immunostimulatory effect in HIV-infected patients. Further studies are needed to demonstrate whether beta-carotene has a role as adjunct therapy in treatment of HIV-infected patients.
据报道，β-胡萝卜素具有免疫刺激作用。最近的研究表明，补充β-胡萝卜素可增加HIV感染患者的CD4细胞计数。我们的双盲、安慰剂对照临床试验旨在测试β-胡萝卜素提高HIV感染患者CD4细胞计数的疗效。21名HIV血清阳性患者被随机分为两组，一组每天服用180毫克β-胡萝卜素，另一组服用安慰剂，为期4周，然后交叉接受另一种治疗，为期4周。与安慰剂相比，β-胡萝卜素使白细胞总数显著增加（p = 0.01），CD4细胞计数变化百分比（p = 0.02），以及CD4/CD8比值变化百分比（p = 0.02）。服用胡萝卜素期间，绝对CD4细胞计数、绝对CD4/CD8比值以及总淋巴细胞和B淋巴细胞均增加，而服用安慰剂期间则下降，但这些差异未达到统计学显著性。两种治疗均未观察到毒性。β-胡萝卜素似乎对HIV感染患者具有免疫刺激作用。需要进一步研究以证明β-胡萝卜素是否在HIV感染患者的治疗中作为辅助疗法发挥作用。
