Ullrich R, Schneider T, Heise W, Schmidt W, Averdunk R, Riecken E O, Zeitz M
Department of Medicine, Klinikum Steglitz, Free University of Berlin, Germany.
AIDS. 1994 May;8(5):661-5. doi: 10.1097/00002030-199405000-00013.
To assess total serum carotene concentration in HIV-infected patients as an indicator of fat malabsorption in correlation with diarrhoea, secondary enteric infections, and blood lymphocyte subsets.
Prospective study.
Two referral-based tertiary care centres in Berlin, Germany.
A total of 33 controls and 116 HIV-infected patients who had complete microbiological evaluation of stools and biopsies obtained at upper endoscopy because of diarrhoea (n = 54), or other symptoms (n = 62), were studied.
Total serum carotene concentration was determined spectrophotometrically.
Total serum carotene concentration was abnormal (< 0.88 mumol/l) in 77% of HIV-infected patients and significantly decreased compared with controls [0.47 mumol/l (range, 0.06-1.69 mumol/l) versus 1.37 mumol/l (range, 0.88-2.92 mumol/l); P < 0.0001]. Total serum carotene concentration did not differ between AIDS patients and patients at earlier disease stages, between patients with or without secondary enteric infections, or between patients with or without fever. In patients at earlier disease stages, but not in AIDS patients, total serum carotene concentration was lower for patients with than without diarrhoea. The percentage of CD4 lymphocytes (r = 0.364; P < 0.001), CD4 count (r = 0.28; P = 0.0013), and CD4/CD8 ratio (r = 0.38; P < 0.001) in the peripheral blood correlated with total serum carotene levels in HIV-infected patients.
HIV-infected patients frequently have abnormal total serum carotene concentrations indicating fat malabsorption which may contribute to diarrhoea. Furthermore, total serum carotene concentrations correlate with immunologic abnormalities in HIV infection.
评估HIV感染患者的血清总胡萝卜素浓度，作为脂肪吸收不良的指标，并与腹泻、继发性肠道感染和血液淋巴细胞亚群进行相关性分析。
前瞻性研究。
德国柏林的两家基于转诊的三级护理中心。
共研究了33名对照者和116名HIV感染患者，这些患者因腹泻（n = 54）或其他症状（n = 62）接受了粪便的完整微生物学评估以及上消化道内镜检查时获取的活检组织。
采用分光光度法测定血清总胡萝卜素浓度。
77%的HIV感染患者血清总胡萝卜素浓度异常（< 0.88 μmol/L），与对照组相比显著降低[0.47 μmol/L（范围，0.06 - 1.69 μmol/L）对1.37 μmol/L（范围，0.88 - 2.92 μmol/L）；P < 0.0001]。艾滋病患者与疾病早期患者之间、有或无继发性肠道感染的患者之间、有或无发热的患者之间，血清总胡萝卜素浓度无差异。在疾病早期患者中，有腹泻的患者血清总胡萝卜素浓度低于无腹泻的患者，但在艾滋病患者中并非如此。外周血中CD4淋巴细胞百分比（r = 0.364；P < 0.001）、CD4计数（r = 0.28；P = 0.0013）和CD4/CD8比值（r = 0.38；P < 0.001）与HIV感染患者的血清总胡萝卜素水平相关。
HIV感染患者常有异常的血清总胡萝卜素浓度，提示脂肪吸收不良，这可能导致腹泻。此外，血清总胡萝卜素浓度与HIV感染中的免疫异常相关。
