多米尼加共和国性病诊所中的HIV-1和HTLV-I

HIV-1 and HTLV-I in sexually transmitted disease clinics in the Dominican Republic.

作者信息

Rodriguez E M, de Moya E A, Guerrero E, Monterroso E R, Quinn T C, Puello E, de Quiñones M R, Thorington B, Glasner P D, Zacarias F

机构信息

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

J Acquir Immune Defic Syndr (1988). 1993 Mar;6(3):313-8.

PMID:8450407

Abstract

A cross-sectional seroprevalence study of human immunodeficiency virus type 1 (HIV-1) and human T-cell lymphotropic virus type I (HTLV-I) was undertaken among 494 attendees in two Santo Domingo sexually transmitted disease clinics in 1989. All participants were evaluated for Neisseria gonorrhoeae, Chlamydia trachomatis, syphilis, and genital ulcers. Of the 494 participants, 15 (3.0%) were positive for HIV-1 and 14 (2.8%) were positive for HTLV-I. Twelve of 371 (3.2%) men were HIV-1 seropositive: 0 of 68 homosexual/bisexual and 12 (4.0%) of 302 heterosexual men (one seronegative male could not be classified). Three (2.4%) of 123 women were HIV-1 seropositive. One (1.5%) homosexual/bisexual man, five (1.7%) heterosexual men, and eight (6.5%) women were HTLV-I seropositive. Among heterosexual men, HIV-1 was associated with multiple lifetime sex partners (O.R. = 5.9; 95% C.I. = 1.4, 23; p = 0.007). HIV-1 was associated with genital ulcer disease among women (p = 0.004). Among women, HTLV-I was associated with professional sex work (O.R. = 18; 95% C.I. = 2.1, > 100; p = 0.001). These findings suggest the need for control of sexually transmitted diseases and targeted educational programs for prevention of HIV-1 and HTLV-I among individuals with high-risk behaviors in the Dominican Republic.

摘要

1989年，在圣多明各的两家性病诊所对494名就诊者进行了一项关于1型人类免疫缺陷病毒（HIV-1）和I型人类嗜T细胞病毒（HTLV-I）的横断面血清流行率研究。所有参与者都接受了淋病奈瑟菌、沙眼衣原体、梅毒和生殖器溃疡的检测。在494名参与者中，15人（3.0%）HIV-1呈阳性，14人（2.8%）HTLV-I呈阳性。371名男性中有12人（3.2%）HIV-1血清学呈阳性：68名同性恋/双性恋男性中0人，302名异性恋男性中有12人（4.0%）（一名血清学阴性男性无法分类）。123名女性中有3人（2.4%）HIV-1血清学呈阳性。1名（1.5%）同性恋/双性恋男性、5名（1.7%）异性恋男性和8名（6.5%）女性HTLV-I血清学呈阳性。在异性恋男性中，HIV-1与多个性伴侣相关（比值比=5.9；95%可信区间=1.4，23；p=0.007）。HIV-1与女性生殖器溃疡疾病相关（p=0.004）。在女性中，HTLV-I与职业性工作相关（比值比=18；95%可信区间=2.1，>100；p=0.001）。这些发现表明，在多米尼加共和国，需要控制性传播疾病，并针对有高危行为的个体开展预防HIV-1和HTLV-I的针对性教育项目。