Ito T, Suyama K, Tsukahara R, Matsuoka H, Yokose N, Miyake K, An E, Futaki M, Inokuchi K, Ogata K
Third Department of Internal Medicine, Nippon Medical School.
Rinsho Ketsueki. 1993 Jan;34(1):50-6.
Two cases of acute leukemia with a t (6;9) (p23;34) chromosome abnormality are reported. The first case was a 34-year-old female who was hospitalized in October 1989. A diagnosis of FAB-M1 was made. Chromosomal analysis of the bone marrow cells showed a 46, XX, t (6;9) (p23;q34). Complete remission was achieved after two courses of BHAC-DMP therapy. In September 1991, at the time of relapse, chromosomal analysis revealed two abnormal clones consisting of a 46, XX, t (6;9) (p23;q34), -12, -17, +der (12) t (12;17) (p11.2;q11.2) with a residual normal clone. She died in February 1992. The second case was a 42-year-old male who was hospitalized in January 1990. He was diagnosed as having RAEB. Chromosomal analysis of the bone marrow cells showed 46, XY, t (6;9) (p23;q34). Three months later, the disease progressed to acute leukemia accompanied by leg ulceration with leukemic cell infiltration. Small-dose ara-C therapy was given, but with no effect. After two subsequent courses of therapy with low-dose etoposide, complete remission was achieved. Four months later, relapse occurred, and the patient died of sepsis in February 1991. In the literature, 31 cases of myeloproliferative disorders with t (6;9) have been reported.
报告了2例伴有t(6;9)(p23;34)染色体异常的急性白血病。第一例为一名34岁女性，于1989年10月住院。诊断为FAB-M1。骨髓细胞染色体分析显示为46,XX,t(6;9)(p23;q34)。经两个疗程的BHAC-DMP治疗后达到完全缓解。1991年9月复发时，染色体分析显示两个异常克隆，分别为46,XX,t(6;9)(p23;q34),-12,-17,+der(12)t(12;17)(p11.2;q11.2)，伴有一个残留的正常克隆。她于1992年2月死亡。第二例为一名42岁男性，于1990年1月住院。他被诊断为RAEB。骨髓细胞染色体分析显示为46,XY,t(6;9)(p23;q34)。三个月后，疾病进展为急性白血病，伴有腿部溃疡及白血病细胞浸润。给予小剂量阿糖胞苷治疗，但无效。随后经两个疗程的小剂量依托泊苷治疗后达到完全缓解。四个月后复发，患者于1991年2月死于败血症。文献中已报道31例伴有t(6;9)的骨髓增殖性疾病。
