艾滋病患者鸟分枝杆菌-胞内分枝杆菌播散性感染
[Mycobacterium avium-intracellulare disseminated infection in patients with AIDS].
作者信息
Herrero Martínez J A, Sánchez Manzano M D, Palenque Mataix E, Medina Iglesias P, Sánchez Rivas J L, Rubio García R, Costa Pérez-Herrero J R
机构信息
Unidad de Enfermedades Infecciosas, Hospital 12 de Octubre, Madrid.
出版信息
Med Clin (Barc). 1993 Feb 6;100(5):171-3.
BACKGROUND
Disseminated infection by Mycobacterium avium-intracellulare is almost exclusively produced in individuals with HIV infection. The incidence of this infection in Spain is unknown.
METHODS
The clinical and microbiologic registries of 30 patients with AIDS and disseminated infection by Mycobacterium avium are reviewed.
METHODS
Twenty-three percent of the patients with AIDS had, at some time in their evolution, disseminated infection by M. avium. The clinical picture included prolonged fever, digestive symptoms, weight loss and appearance of lymph node enlargement. This infection appeared in patients with severe alteration of cellular immunity (mean CD4 lymphocytes: 0.19 x 10(9)/l). Although medium term prognosis was bad the causes of death of the patients were other opportunistic diseases related with the immunodeficiency.
CONCLUSIONS
Infection by Mycobacterium avium is frequent among the population of individuals with HIV infection. With the appearance of prolonged fever in a patient with HIV infection and CD4 lymphocyte count lower than 0.2 x 10(9)/1 appropriate microbiologic studies including blood cultures for mycobacteria should be initiated.
背景
鸟分枝杆菌-胞内分枝杆菌播散性感染几乎仅发生于HIV感染个体。在西班牙，这种感染的发病率尚不清楚。
方法
回顾了30例艾滋病合并鸟分枝杆菌播散性感染患者的临床和微生物学记录。
方法
23%的艾滋病患者在病程中的某个时间出现了鸟分枝杆菌播散性感染。临床表现包括长期发热、消化系统症状、体重减轻和淋巴结肿大。这种感染出现在细胞免疫严重受损的患者中（平均CD4淋巴细胞：0.19×10⁹/L）。尽管中期预后不佳，但患者的死亡原因是与免疫缺陷相关的其他机会性疾病。
结论
鸟分枝杆菌感染在HIV感染人群中很常见。当HIV感染患者出现长期发热且CD4淋巴细胞计数低于0.2×10⁹/L时，应启动包括分枝杆菌血培养在内的适当微生物学检查。
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