Hamann G, Meier T, Schimrigk K
Neurologische Abteilung Universitätsnervenklinik, Universität des Saarlandes, Homburg/Saar.
Nervenarzt. 1993 Feb;64(2):104-7.
A retrospective study compared a group of 122 patients with brain metastases from unknown primaries with a second group of 121 patients, who developed brain metastases in the course of a known malignant disease. Special attention was paid to the kind of primary cancer, therapeutic influences and prognostic differences. The results pointed to a late occurrence of brain metastases in breast cancer, no patient with this type of cancer being found in group 1. Melanoma and colorectal cancer were also found predominantly in group 2, whereas lung cancer was the most common cause of metastasis in group 1 and the most frequent cancer in both groups. Clinical course, therapy and outcome showed no significant differences between the two groups. Mean survival time was 4.6 (+/- 6) months for the patient series as a whole. Patients with breast cancer had a significantly higher survival rate than those with other forms of cancer. Localisation and degree of malignancy mainly determine the life-prognosis, the type and intensity of therapy being of secondary importance.
一项回顾性研究将一组122例原发灶不明的脑转移瘤患者与另一组121例在已知恶性疾病过程中发生脑转移瘤的患者进行了比较。特别关注了原发癌的类型、治疗影响和预后差异。结果表明，乳腺癌脑转移发生较晚，在第1组中未发现此类癌症患者。黑色素瘤和结直肠癌也主要出现在第2组，而肺癌是第1组转移的最常见原因，也是两组中最常见的癌症。两组的临床病程、治疗和结果无显著差异。整个患者系列的平均生存时间为4.6（±6）个月。乳腺癌患者的生存率明显高于其他癌症患者。肿瘤的定位和恶性程度主要决定生存预后，治疗的类型和强度次要。
