Uribarri J, Oh M S
Department of Medicine, Mount Sinai Medical Center, New York, NY 10029-6574.
Nephron. 1993;63(2):172-5. doi: 10.1159/000187178.
We describe a case of renal hypouricemia due to increased tubular secretion of urate associated with absorptive hypercalciuria. This association has been described in the past, but this is the first time that high plasma levels of 1,25-dihydroxyvitamin D have been reported. A possible cause-and-effect relation between altered uric acid transport and altered vitamin D metabolism in the proximal tubule is suggested.
我们描述了一例因肾小管尿酸分泌增加伴吸收性高钙尿症导致的肾性低尿酸血症病例。过去曾有过这种关联的描述,但此次是首次报告血浆1,25 - 二羟维生素D水平升高。提示近端肾小管中尿酸转运改变与维生素D代谢改变之间可能存在因果关系。