Muramoto K, Ono T, Nishijo H, Fukuda M
Department of Electrical and Computer Engineering, Faculty of Technology, Kanazawa University, Japan.
Neuroscience. 1993 Feb;52(3):621-36. doi: 10.1016/0306-4522(93)90411-8.
To investigate amygdaloid contribution to stimulus-affect association and to emotional behavior, single neuron activity was recorded in the basolateral and corticomedial amygdala of the rat amygdala during discrimination of conditioned cue tones associated with positive (glucose and intracranial self-stimulation) and negative (weak electric footshock) unconditioned stimuli. Amygdaloid neurons that responded to two rewarding unconditioned stimuli responded in the same manner to both. Responses to conditioned cue tones and those to rewards were also significantly related, suggesting that amygdaloid neuronal responses to conditioned stimuli are closely related to the affective nature of the corresponding unconditioned stimulation. These might be neuronal functions that underlie stimulus-affect association in the amygdala. In random repeated trials, including acquisition to conditioned cue tones and extinction after acquisition, response plasticity was more evident in basolateral than in corticomedial neurons. Furthermore, more basolateral than corticomedial neurons differentiated glucose and its cue from intracranial self-stimulation and its cue by responding to one but not the other. More basolateral than corticomedial neurons were excited by intracranial self-stimulation and its cue and inhibited by footshock and its cue. The differences between the two nuclear groups suggest that basolateral neurons are more plastic and discriminative, and corticomedial neurons respond indiscriminately to positive and negative unconditioned or conditioned stimuli. The results indicate amygdaloid neuron involvement in stimulus-affect association. Basolateral neurons may be more involved than corticomedial neurons in discriminating and learning conditioned stimuli.
为了研究杏仁核在刺激-情感关联及情绪行为中的作用，在大鼠杏仁核的基底外侧和皮质内侧杏仁核中记录单个神经元的活动，记录过程发生在对与阳性（葡萄糖和颅内自我刺激）和阴性（弱电足电击）非条件刺激相关的条件提示音进行辨别期间。对两种奖励性非条件刺激有反应的杏仁核神经元，对两者的反应方式相同。对条件提示音的反应与对奖励的反应也显著相关，这表明杏仁核神经元对条件刺激的反应与相应非条件刺激的情感性质密切相关。这些可能是杏仁核中刺激-情感关联的神经功能基础。在随机重复试验中，包括对条件提示音的习得和习得后的消退，基底外侧神经元的反应可塑性比皮质内侧神经元更明显。此外，与皮质内侧神经元相比，更多的基底外侧神经元通过对其中一种而非另一种做出反应，从而区分葡萄糖及其提示与颅内自我刺激及其提示。与皮质内侧神经元相比，更多的基底外侧神经元受到颅内自我刺激及其提示的兴奋，并受到电击及其提示的抑制。这两个核团之间的差异表明，基底外侧神经元更具可塑性和辨别力，而皮质内侧神经元对阳性和阴性非条件或条件刺激无差别地做出反应。结果表明杏仁核神经元参与刺激-情感关联。在辨别和学习条件刺激方面，基底外侧神经元可能比皮质内侧神经元参与程度更高。
