Meyerhoff D J, MacKay S, Bachman L, Poole N, Dillon W P, Weiner M W, Fein G
Neurology. 1993 Mar;43(3 Pt 1):509-15. doi: 10.1212/wnl.43.3_part_1.509.
We used magnetic resonance imaging (MRI) and water-suppressed proton magnetic resonance spectroscopic imaging to study the effects of human immunodeficiency virus (HIV) infection on the brains of 10 individuals with cognitive impairment due to HIV and seven normal controls. 1H spectra from nine 2.5-ml volumes in the centrum semiovale and the mesial cortex showed significantly reduced N-acetylaspartate (NAA) relative to choline and creatine in the cognitively impaired HIV-infected subjects. This reduction was due to a nonlocalized decrease of NAA in these patients, only two of whom had moderate atrophy and white matter signal hyperintensities on MRI. Since NAA is a putative neuronal marker, the findings suggest neuronal damage in early stages of HIV infection that is not evident on standard MRI and are consistent with the neuropathologically known neuronal loss.
我们使用磁共振成像（MRI）和水抑制质子磁共振波谱成像，研究了人类免疫缺陷病毒（HIV）感染对10名因HIV导致认知障碍的个体及7名正常对照者大脑的影响。在半卵圆中心和内侧皮质的9个2.5毫升容积区域所采集的氢谱显示，与胆碱和肌酸相比，认知受损的HIV感染受试者的N-乙酰天门冬氨酸（NAA）显著减少。这种减少是由于这些患者的NAA呈非局限性降低，其中只有两名患者在MRI上有中度萎缩和白质信号高增强。由于NAA是一种假定的神经元标志物，这些发现提示HIV感染早期存在神经元损伤，而这在标准MRI上并不明显，并且与神经病理学上已知的神经元丢失情况相符。
