Gordon T L, Meehan S M, Schechter M D
Department of Pharmacology, College of Medicine, Northeastern Ohio Universities, Rootstown 44272.
Pharmacol Biochem Behav. 1993 Mar;44(3):657-9. doi: 10.1016/0091-3057(93)90182-s.
The locomotor stimulatory effects of nicotine (0.4 and 0.8 mg/kg) and cathinone (0.5 and 1.0 mg/kg) were assessed in alcohol-preferring (P) and -nonpreferring (NP) rats. Whereas P rats demonstrated enhanced (0.8 mg/kg) or no change (0.4 mg/kg) in spontaneous locomotor activity (SMA) to nicotine, NP animals showed no change (0.4 mg/kg) or depression of activity (0.8 mg/kg). However, following cathinone administration both P and NP rats exhibited an increase in SMA. The above results are discussed in light of the genotypic variations between P/NP rats and the potential mediation of differential neurotransmitter effects in the two lines.
在嗜酒（P）和非嗜酒（NP）大鼠中评估了尼古丁（0.4和0.8毫克/千克）和卡西酮（0.5和1.0毫克/千克）对运动的刺激作用。P大鼠对尼古丁的自发运动活动（SMA）增强（0.8毫克/千克）或无变化（0.4毫克/千克），而NP动物则无变化（0.4毫克/千克）或活动受到抑制（0.8毫克/千克）。然而，给予卡西酮后，P和NP大鼠的SMA均增加。根据P/NP大鼠之间的基因型差异以及两条品系中不同神经递质效应的潜在介导作用对上述结果进行了讨论。
