抗体反应及某些行为作为两种近交系小鼠（C57BL/6和BALB/c）之间的差异性状。

Antibody response and some behaviors as differential traits between two inbred strains of mice (C57BL/6 and BALB/c).

作者信息

Vidal J, Fusté A

机构信息

Departamento de Personalidad, Evaluación y Tratamiento Psicológicos, Facultad de Psicología, Universidad de Barcelona, Spain.

出版信息

Psychol Rep. 1993 Feb;72(1):111-20. doi: 10.2466/pr0.1993.72.1.111.

DOI:10.2466/pr0.1993.72.1.111

PMID:8451341

Abstract

The goals of this research were to find out if the antibody response and some behaviors are differential traits for murine strains C57BL/6 and BALB/c and to study the influence of strain and isolation on both behavior and the antibody response. 21 C57BL/6 male mice and 28 BALB/c male mice were used; of those, 11 C57BL/6 and 16 BALB/c were kept isolated, and the remaining mice were housed 2 per cage. The tests were Open-fields 1, 2, and 3 (of varying light and sound stimulation), holeboard, light-darkness test, immunization with rat erythrocytes; in addition, the mice were weighed. The traits that best differentiated both strains (according to discriminant analysis) were weight, IgM primary response, and emotional behavior (ambulation, rearing, and defecation in stimulating open-fields). Social isolation (of adult mice) influenced emotional behavior, but not the antibody response.

摘要

本研究的目的是确定抗体反应和某些行为是否是小鼠品系C57BL/6和BALB/c的差异性状，并研究品系和隔离对行为及抗体反应的影响。使用了21只C57BL/6雄性小鼠和28只BALB/c雄性小鼠；其中，11只C57BL/6和16只BALB/c保持隔离状态，其余小鼠每笼饲养2只。测试包括开放场1、2和3（不同的光照和声音刺激）、洞板试验、明暗试验、用大鼠红细胞进行免疫；此外，还对小鼠进行了称重。（根据判别分析）最能区分这两个品系的性状是体重、IgM初次反应以及情绪行为（在刺激开放场中的走动、竖毛和排便）。（成年小鼠的）社会隔离影响情绪行为，但不影响抗体反应。