Hoffman R E, McGlashan T H
Yale Psychiatric Institute, New Haven, CT 06520.
Schizophr Bull. 1993;19(1):15-9. doi: 10.1093/schbul/19.1.15.
The term, "neurodynamics," refers to interactions of large numbers of neurons that, in the short term, transform input information derived from their environments into meaningful outputs and, in the long term, use this information to alter their own architectures. This general concept may be useful in framing and investigating research questions that could advance our understanding of the nature, course, and treatment of schizophrenia. The mechanism of action of neuroleptics, the anatomic localization of schizophrenia, the stability of associated brain disturbances over time, and the distinction of state versus trait variables are briefly discussed as examples of issues whose understanding may be enhanced by a neurodynamic perspective.
术语“神经动力学”指的是大量神经元之间的相互作用，短期内，这些相互作用将来自其环境的输入信息转化为有意义的输出，长期来看，则利用这些信息改变自身结构。这一总体概念可能有助于构建和研究相关研究问题，从而推进我们对精神分裂症的本质、病程及治疗的理解。作为一些问题的示例，本文简要讨论了抗精神病药物的作用机制、精神分裂症的解剖定位、相关脑功能障碍随时间的稳定性，以及状态变量与特质变量的区别，通过神经动力学视角理解这些问题可能会有所助益。
