Frick S, Frick P
Medizinische Klinik, Universitätsspital Zürich.
Schweiz Med Wochenschr. 1993 Feb 27;123(8):328-34.
We describe three patients with chronic lymphocytic leukemia who had a complete spontaneous remission, and review the cases reported in the literature. The mechanism leading to spontaneous remission is unknown, but it is speculated that the loss of a leukemia inducing oncogene or the reappearance of a leukemia suppressor gene could be involved. The interesting observation that, in some reported patients, the remission followed a viral infection, raises the question whether a virus-induced defense mechanism plays a causal role.
我们描述了三名慢性淋巴细胞白血病患者出现完全自发缓解的情况，并回顾了文献中报道的病例。导致自发缓解的机制尚不清楚，但据推测可能涉及白血病诱导癌基因的缺失或白血病抑制基因的重新出现。一个有趣的现象是，在一些报道的患者中，缓解发生在病毒感染之后，这就提出了一个问题，即病毒诱导的防御机制是否起了因果作用。
