Kringlen E
Department of Psychiatry, Vinderen, University of Oslo, Norway.
Acta Psychiatr Scand Suppl. 1993;370:79-84. doi: 10.1111/j.1600-0447.1993.tb05365.x.
Methodological questions in heredity-environment studies are discussed with special emphasis on schizophrenia and severe affective disorder. Mental disorder is a matter of behavioral and experimental manifestations, caused by complex interactions of genes and environment operating over a lifespan. It is therefore necessary to combine different research strategies in order to advance this field. However, progress in research is hampered by problems in classification and definition of phenotype. Accordingly, family, adoption and twin studies have a lot to contribute before molecular genetic research might be carried out.
本文讨论了遗传-环境研究中的方法学问题，特别强调了精神分裂症和重度情感障碍。精神障碍是行为和实验表现的问题，由基因和环境在整个生命周期中的复杂相互作用引起。因此，有必要结合不同的研究策略来推动该领域的发展。然而，研究进展受到表型分类和定义问题的阻碍。因此，在进行分子遗传学研究之前，家族、收养和双胞胎研究有很多可做的贡献。
