Hu L B, Lucio B, Schat K A
Department of Avian and Aquatic Animal Medicine, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853.
Avian Dis. 1993 Jan-Mar;37(1):157-69.
Embryonally bursectomized (Ebx) chickens developed signs and lesions typical of chicken infectious anemia (CIA) when infected with CIA-1 isolate of chicken infectious anemia virus (CIAV) at 21 or 38 days of age. In both cases, the chickens had low hematocrit values after the 14th day of inoculation, and the percentage of CD4+ and CD8+ cells in the thymus was markedly reduced at 21 days postinoculation. Even though intact chickens became infected, they never developed low hematocrit values. The data support the hypothesis that age-related resistance to CIA is antibody-mediated and is not due to disappearance of the CIAV target cell; the data also suggest that CD4+/CD8+ cells are the target for infection.
胚胎期切除法氏囊（Ebx）的鸡在21日龄或38日龄感染鸡传染性贫血病毒（CIAV）的CIA - 1分离株时，会出现鸡传染性贫血（CIA）的典型症状和病变。在这两种情况下，接种后第14天鸡的血细胞比容值较低，接种后21天胸腺中CD4 +和CD8 +细胞的百分比显著降低。尽管未切除法氏囊的鸡被感染，但它们从未出现过血细胞比容值降低的情况。这些数据支持以下假设：与年龄相关的对CIA的抵抗力是由抗体介导的，并非由于CIAV靶细胞的消失；数据还表明CD4 + / CD8 +细胞是感染的靶标。
