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[利福平试验在吉尔伯特综合征诊断中的应用]

[The rifampicin test in the diagnosis of Gilbert syndrome].

作者信息

Velilla Alcubilla J P, García Mauriz E, Martínez Bruna M S, Abinzano M L, Martínez Velasco M C

机构信息

Servicio de Medicina Interna, Hospital de Navarra, Pamplona.

出版信息

Aten Primaria. 1993 Feb 1;11(2):84-6.

PMID:8452997
Abstract

OBJECTIVE

To show the effectiveness and feasibility of the Rifampicin test in diagnosing Gilbert's syndrome.

DESIGN

A prospective, descriptive study. SITE. General Medical Service of the Navarra Hospital.

PATIENTS

17 patients with bilirubin levels on two or more occasions and 6 healthy patients without these data. Both in- and out-patients.

MAIN MEASUREMENTS AND RESULTS

The Rifampicin test. Bilirubin levels were determined when fasting and one, two, three and four hours after taking 900 mg of Rifampicin (Rimactan). After the test, those patients who had Gilbert's disease presented bilirubin levels significantly higher than the healthy patients, who remained within normal levels.

CONCLUSIONS

In the group studied, the Rifampicin test demonstrated its effectiveness in the diagnosis of suspected Gilbert's disease. It would therefore be possible to use this test in the Primary Care field.

摘要

目的

展示利福平试验在诊断吉尔伯特综合征中的有效性和可行性。

设计

一项前瞻性描述性研究。地点:纳瓦拉医院综合医疗服务部。

患者

17例胆红素水平在两个或更多时间点进行检测的患者以及6例无这些数据的健康患者。包括门诊和住院患者。

主要测量指标及结果

利福平试验。在空腹时以及服用900毫克利福平(利美定)后1、2、3和4小时测定胆红素水平。试验后,患有吉尔伯特病的患者胆红素水平显著高于保持在正常水平的健康患者。

结论

在所研究的组中,利福平试验证明了其在疑似吉尔伯特病诊断中的有效性。因此,有可能在初级保健领域使用该试验。

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