Koronakis V, Hughes C
Cambridge University, Department of Pathology, UK.
Semin Cell Biol. 1993 Feb;4(1):7-15. doi: 10.1006/scel.1993.1002.
Bacterial ABC transporter proteins are associated with a great number of cellular processes. While many of the best characterised examples are involved in the import of small molecules into the cell, others mediate export of substrates, especially hydrophilic proteins. This article focuses on these bacterial ABC exporters, in particular the HlyB protein which is central to secretion of the 110 kDa hemolysin across both the cytoplasmic and outer membranes. This is an example of non-conventional protein export which does not require an N-terminal signal sequence or the cellular SecA-dependent machinery.
细菌ABC转运蛋白与大量细胞过程相关。虽然许多最具代表性的例子涉及小分子向细胞内的转运，但其他一些则介导底物的输出，尤其是亲水性蛋白质。本文重点关注这些细菌ABC输出蛋白，特别是HlyB蛋白，它对于110 kDa溶血素跨细胞质膜和外膜的分泌至关重要。这是一种非常规蛋白质输出的例子，它不需要N端信号序列或细胞依赖SecA的机制。
