c-myc在细胞生长中的作用。
The role of c-myc in cell growth.
作者信息
Evan G I, Littlewood T D
机构信息
Biochemistry of the Cell Nucleus Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London, UK.
出版信息
Curr Opin Genet Dev. 1993 Feb;3(1):44-9. doi: 10.1016/s0959-437x(05)80339-9.
PMID:8453273
Abstract
Recent experiments have established that the c-myc oncogene encodes a sequence-specific DNA-binding protein that interacts with a specific intracellular partner, Max, and probably manifests its effects through transcriptional modulation. In addition, the range of biological functions attributed to expression of c-myc has grown to include not only transformation and mitogenesis but also cell death.
摘要
最近的实验证实，c-myc癌基因编码一种序列特异性DNA结合蛋白，该蛋白与特定的细胞内伴侣Max相互作用，并且可能通过转录调节发挥其作用。此外，归因于c-myc表达的生物学功能范围不断扩大，不仅包括转化和有丝分裂，还包括细胞死亡。
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