Jennings C G, Burden S J
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Curr Opin Neurobiol. 1993 Feb;3(1):75-81. doi: 10.1016/0959-4388(93)90038-z.
Major advances have occurred in our understanding of the signaling events involved in neuromuscular synapse formation. In particular, it has recently been shown that agrin is necessary for synapse formation, that acetylcholine receptor genes are specifically transcribed by synaptic nuclei in response to signals from the synaptic basal lamina, and that synaptic competition between motor neurons can occur by a Hebbian mechanism in cell culture.
在我们对神经肌肉突触形成过程中涉及的信号事件的理解方面已经取得了重大进展。特别是，最近已经表明，聚集蛋白对于突触形成是必需的，乙酰胆碱受体基因会由突触核根据来自突触基底层的信号进行特异性转录，并且运动神经元之间的突触竞争可以在细胞培养中通过赫布机制发生。
