老年男性的性激素与骨密度

Sex hormones and bone mineral density in elderly men.

作者信息

Murphy S, Khaw K T, Cassidy A, Compston J E

机构信息

Clinical Gerontology Unit, Addenbrooke's Hospital, Cambridge, UK.

出版信息

Bone Miner. 1993 Feb;20(2):133-40. doi: 10.1016/s0169-6009(08)80022-0.

DOI:10.1016/s0169-6009(08)80022-0

PMID:8453329

Abstract

The aim of this study was to determine the relationships between sex hormones and bone mineral density (BMD) in older men. Community-dwelling men (n = 134, mean age (SD) 69.5 (3.1) years) were recruited from two general practices in Cambridge, UK. Plasma total testosterone and sex hormone binding globulin (SHBG) were assayed and a free androgen index (FAI) was derived as the ratio of total testosterone to SHBG (x 100). Spine and hip BMD were measured by dual energy x-ray absorptiometry using the Hologic QDR-1000. After adjusting for age and body mass index (BMI), the FAI correlated with femoral neck (r = 0.20, P = 0 0.03), intertrochanteric, trochanteric and Ward's Triangle BMD (r = 0.22, P = 0.01). Analysis of variance, with adjustment for age and BMI, showed a progressive upward trend of hip BMD with increasing quartiles of FAI. The findings suggest that free testosterone plays a role in determining bone mineral density in older men.

摘要

本研究的目的是确定老年男性性激素与骨密度（BMD）之间的关系。从英国剑桥的两家普通诊所招募了社区居住男性（n = 134，平均年龄（标准差）69.5（3.1）岁）。检测血浆总睾酮和性激素结合球蛋白（SHBG），并计算游离雄激素指数（FAI），即总睾酮与SHBG的比值（×100）。使用Hologic QDR - 1000通过双能X线吸收法测量脊柱和髋部骨密度。在调整年龄和体重指数（BMI）后，FAI与股骨颈骨密度相关（r = 0.20，P = 0.03），与粗隆间、大粗隆和沃德三角区骨密度相关（r = 0.22，P = 0.01）。在调整年龄和BMI后进行的方差分析显示，随着FAI四分位数的增加，髋部骨密度呈逐渐上升趋势。研究结果表明，游离睾酮在老年男性骨密度的决定中起作用。