Chollat-Namy A, Delamanche I S, Bouchaud C
Laboratoire de Cytologie, Université Pierre et Marie Curie, CNRS, URA 1488, Paris, France.
Brain Res. 1993 Feb 12;603(1):32-7. doi: 10.1016/0006-8993(93)91296-5.
A massive and transitory increase in c-fos mRNA and Fos protein occurred in rats intoxicated by a single dose of soman (organophosphate compound and irreversible cholinesterase inhibitor) only in animals that had seizures. Comparison of immunohistochemistry that localizes Fos protein and of in situ hybridization that localizes its mRNA showed that there was an early and explosive expression of mRNA in many cerebral regions followed by transitory immunoreactivity in only some regions (piriform cortex, entorhinal area, hippocampus). The levels of mRNA and c-fos-like immunoreactivity decreased slowly and returned to basal level 24 h after soman administration.
单次给予梭曼（有机磷化合物及不可逆胆碱酯酶抑制剂）使大鼠中毒后，仅在出现惊厥的动物中，c-fos信使核糖核酸（mRNA）和Fos蛋白出现大量且短暂的增加。对定位Fos蛋白的免疫组织化学和定位其mRNA的原位杂交进行比较显示，许多脑区mRNA有早期爆发性表达，随后仅在某些区域（梨状皮质、内嗅区、海马体）出现短暂的免疫反应性。给予梭曼24小时后，mRNA水平和c-fos样免疫反应性缓慢下降并恢复至基础水平。
