一例伴有染色体异常ins(5;2)(q13;p21p25)和2p缺失的复发性软骨黏液样纤维瘤：病例报告
A recurrent chondromyxoid fibroma with chromosome aberrations ins(5;2)(q13;p21p25) and 2p deletion: a case report.
作者信息
Tarkkanen M, Böhling T, Heliö H, Karaharju E, Kaipainen A, Szymanska J, Elomaa I, Knuutila S
机构信息
Department of Medical Genetics, University of Helsinki, Finland.
出版信息
Cancer Genet Cytogenet. 1993 Feb;65(2):141-6. doi: 10.1016/0165-4608(93)90223-9.
We report a patient with a recurrent chondromyxoid fibroma, a rare benign tumor of the bone with clonal aberrations in chromosomes 2 and 5. Karyotyping, chromosome painting, interphase cytogenetics by in situ hybridization, and DNA flow cytometry were used. The karyotype was interpreted as 46,XX,der(2)ins(5;2)(q13;p21p25),der(2)ins(5;2)(q13;p21p25), der(5)ins(5;2) (q13;p21p25).
我们报告了一例复发性软骨黏液样纤维瘤患者，这是一种罕见的骨良性肿瘤，在染色体2和5上存在克隆性畸变。采用了核型分析、染色体描绘、原位杂交间期细胞遗传学和DNA流式细胞术。核型解释为46,XX，der(2)ins(5;2)(q13;p21p25)，der(2)ins(5;2)(q13;p21p25)，der(5)ins(5;2)(q13;p21p25)。
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