一名慢性淋巴细胞白血病患者出现包括t(8;22)在内的复杂核型异常。
Complex karyotypic abnormalities including t(8;22) in a patient with chronic lymphocytic leukemia.
作者信息
Xue Y, Yu F, Zhou Z, He Z, Guo Y, Wang M, Lin B
机构信息
Jiangsu Institute of Hematology, Leukemia Research Unit, Suzhou, Peoples Republic of China.
出版信息
Cancer Genet Cytogenet. 1993 Feb;65(2):157-60. doi: 10.1016/0165-4608(93)90226-c.
PMID:8453602
Abstract
The case of a 49-year-old Chinese man with B-cell chronic lymphocytic leukemia (B-CLL) is presented. Complex karyotypic abnormalities comprising t(8;22)(q24;q11), trisomy 7, a deletion of 11q, and two small marker chromosomes were observed in PWM-stimulated cultures of his peripheral blood cells. To our knowledge, this is the first report of a t(8;22) in CLL.
摘要
本文报告了一例49岁中国男性B细胞慢性淋巴细胞白血病（B-CLL）患者。在其外周血细胞的PWM刺激培养物中观察到复杂的核型异常，包括t(8;22)(q24;q11)、三体7、11q缺失和两条小标记染色体。据我们所知，这是CLL中t(8;22)的首次报告。
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