新的染色体异常。1例B细胞慢性淋巴细胞白血病患者存在t(1;19;?)。

New chromosomal abnormality. t(1;19;?) in a case of B-chronic lymphocytic leukemia.

作者信息

Montero S, Caballín M R, Coll M D, Besses C, Woessner S, Egozcue J, Solé F

机构信息

Department of Biologia Animal, Biologia Vegetal i Ecologia, Universitat Autònoma de Barcelona, Spain.

出版信息

Cancer Genet Cytogenet. 1992 Jun;60(2):131-4. doi: 10.1016/0165-4608(92)90004-r.

DOI:10.1016/0165-4608(92)90004-r

PMID:1606555

Abstract

Cytogenetic analysis was performed on peripheral blood cells stimulated with interleukin 6 (IL-6), lipopolysaccharide from Escherichia coli (LPS), phytohemagglutinin (PHA), pokeweed mitogen (PWM) and tetradecanoyl-phorbol-acetate (TPA), in a patient with B-chronic lymphocytic leukemia, showing a t(1;19;?) translocation as the sole abnormality. To our knowledge, this translocation has not been described before in any human neoplasia. In this case, the poor response to therapy (survival time 4 months) suggested that t(1;19;?) could be related to an aggressive course of the disease.

摘要

对一名B型慢性淋巴细胞白血病患者的外周血细胞进行了细胞遗传学分析，这些外周血细胞用白细胞介素6（IL-6）、大肠杆菌脂多糖（LPS）、植物血凝素（PHA）、商陆有丝分裂原（PWM）和十四酰佛波醇乙酸酯（TPA）刺激，结果显示t(1;19;?)易位是唯一异常。据我们所知，这种易位在任何人类肿瘤中此前均未被描述过。在该病例中，对治疗的不良反应（生存时间4个月）提示t(1;19;?)可能与疾病的侵袭性病程有关。