两个神经母细胞瘤的染色体分析。

Chromosomal analysis of two neuroblastomas.

作者信息

Petković I, Nakić M, Cepulić M, Konja J

机构信息

Institute for Mother and Child Health, Faculty of Medicine, University of Zagreb, Croatia.

出版信息

Cancer Genet Cytogenet. 1993 Feb;65(2):167-9. doi: 10.1016/0165-4608(93)90228-e.

DOI:10.1016/0165-4608(93)90228-e

PMID:8453603

Abstract

We report the results of cytogenetic analysis in two children with neuroblastoma. The analysis was performed on slides obtained from a 24-hour bone marrow (BM) culture or by a direct method of the primary tumor tissue. The structural and numeric karyotype aberrations were established, including structural aberrations of chromosome 1. The finding of i(1q) and t(1;5)(p22;q13) is of interest because these chromosome aberrations are rare in this type of disease.

摘要

我们报告了两名神经母细胞瘤患儿的细胞遗传学分析结果。分析是在取自24小时骨髓（BM）培养的玻片上或通过原发性肿瘤组织的直接方法进行的。确定了结构和数量染色体畸变，包括1号染色体的结构畸变。i(1q)和t(1;5)(p22;q13)的发现很有意思，因为这些染色体畸变在这类疾病中很罕见。