CD8通过布氏布氏锥虫释放的一种分子在淋巴细胞激活过程中起关键作用。
CD8 is critically involved in lymphocyte activation by a T. brucei brucei-released molecule.
作者信息
Olsson T, Bakhiet M, Höjeberg B, Ljungdahl A, Edlund C, Andersson G, Ekre H P, Fung-Leung W P, Mak T, Wigzell H, Fiszer U, Kristensson K
机构信息
Department of Neurology, Karolinska Institute, Huddinge Hospital, Sweden.
出版信息
Cell. 1993 Mar 12;72(5):715-27. doi: 10.1016/0092-8674(93)90400-k.
T. brucei brucei released a lymphocyte triggering factor (TLTF), which triggered purified CD8+, but not CD4+, T cells to interferon gamma (IFN-gamma) mRNA expression and secretion and to [3H]thymidine incorporation. TLTF also induced mRNA for transforming growth factor beta, but not for interleukin-4. The action of this TLTF on mononuclear cell (MNC) cultures was blocked by anti-CD8 antibodies and by soluble CD8. MNCs from a mutant mouse strain lacking CD8 expression were not triggered by TLTF. IFN-gamma provides a growth stimulus for T. brucei brucei, and infected CD8- mice had much lower parasitemia and survived longer than CD8+ mice. The host-parasite interaction in experimental African trypanosomiasis thus involves parasite release of TLTF, which by binding to CD8 triggers CD8+ cells to produce the parasite growth-promoting cytokine IFN-gamma.
布氏布氏锥虫释放一种淋巴细胞触发因子（TLTF），该因子可触发纯化的CD8⁺而非CD4⁺T细胞产生干扰素γ（IFN-γ）mRNA表达和分泌，并促进[³H]胸腺嘧啶核苷掺入。TLTF还可诱导转化生长因子β的mRNA表达，但不能诱导白细胞介素-4的mRNA表达。抗CD8抗体和可溶性CD8可阻断该TLTF对单核细胞（MNC）培养物的作用。来自缺乏CD8表达的突变小鼠品系的MNC不会被TLTF触发。IFN-γ为布氏布氏锥虫提供生长刺激，感染的CD8⁻小鼠的寄生虫血症比CD8⁺小鼠低得多，且存活时间更长。因此，实验性非洲锥虫病中的宿主-寄生虫相互作用涉及寄生虫释放TLTF，TLTF通过与CD8结合触发CD8⁺细胞产生促进寄生虫生长的细胞因子IFN-γ。
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