Baluyut A R, Pollok K E, Bondada S
Department of Microbiology and Immunology, Sanders Brown Center on Aging, Chandler Medical Center, University of Kentucky, Lexington 40536.
Cell Immunol. 1993 Apr 1;147(2):353-66. doi: 10.1006/cimm.1993.1075.
Evidence is presented to demonstrate that murine B lymphocytes receive growth stimulatory signals from their surface class II molecules. Monoclonal anti-Ia antibodies enhanced anti-mu-induced B cell proliferative response. The signals through surface immunoglobulin (Ig) and Ia appeared to act sequentially since preexposure to anti-mu was required to observe anti-Ia-induced increase in B cell proliferation. Anti-Ia antibodies did not increase the number of B cells entering the G1 phase of cell cycle but always enhanced transition from G1 into the S phase in response to stimulation with anti-mu. Analysis of early gene expression revealed that signaling through class II molecules led to an increase in anti-mu-induced expression of c-myc, a proto-oncogene, and of ornithine decarboxylase, a key enzyme in polyamine biosynthesis that has been shown to be intimately related to increased cell proliferation.
有证据表明，小鼠B淋巴细胞从其表面的II类分子接收生长刺激信号。单克隆抗Ia抗体增强了抗μ诱导的B细胞增殖反应。由于需要预先暴露于抗μ才能观察到抗Ia诱导的B细胞增殖增加，因此通过表面免疫球蛋白（Ig）和Ia的信号似乎是顺序作用的。抗Ia抗体并没有增加进入细胞周期G1期的B细胞数量，但总是增强了在抗μ刺激下从G1期向S期的转变。早期基因表达分析表明，通过II类分子的信号传导导致抗μ诱导的原癌基因c-myc和鸟氨酸脱羧酶（多胺生物合成中的关键酶，已被证明与细胞增殖增加密切相关）的表达增加。
