长跑运动员和久坐男性体外血浆胆固醇酯转运蛋白及细胞胆固醇在血浆脂蛋白中的分布

Plasma cholesterol ester transfer protein and distribution of cell cholesterol among plasma lipoproteins in vitro in distance runners and sedentary men.

作者信息

Sutherland W H, Stapely S A, Robertson M C, Nye E R

机构信息

Department of Medicine, University of Otago, Dunedin, New Zealand.

出版信息

Clin Physiol. 1993 Mar;13(2):143-51. doi: 10.1111/j.1475-097x.1993.tb00375.x.

DOI:10.1111/j.1475-097x.1993.tb00375.x

PMID:8453868

Abstract

Plasma cholesteryl ester transfer protein (CETP) activity and distribution of red blood cell (RBC) cholesterol among plasma lipoproteins during incubation of blood were determined in 14 distance runners and 10 sedentary men. Mean plasma CETP activity was similar in the runners (31% 10 microliters-1 18 h-1) and the sedentary men (32% 10 microliters-1 18 h-1). There was significantly (P < 0.05) greater accumulation of cell cholesterol in the HDL fraction (runners: 0.33 mmol l-1; sedentary men: 0.23 mmol l-1) which comprised a significantly (P < 0.05) larger proportion of the total amount of cell cholesterol lost to plasma (runners: 89%; sedentary men: 64%) in incubated blood from the runners. The results of this study suggest that in distance runners, high HDL concentrations are not accompanied by reduced plasma CETP levels but in conjunction with low triglyceride-rich lipoprotein levels in plasma, may promote preferential distribution of cell cholesterol into the 'antiatherogenic' HDL fraction.

摘要

在14名长跑运动员和10名久坐男性中，测定了血液孵育期间血浆胆固醇酯转运蛋白（CETP）活性以及红细胞（RBC）胆固醇在血浆脂蛋白中的分布情况。长跑运动员的平均血浆CETP活性（31%×10微升⁻¹×18小时⁻¹）与久坐男性（32%×10微升⁻¹×18小时⁻¹）相似。高密度脂蛋白（HDL）组分中细胞胆固醇的积累显著更多（P<0.05）（长跑运动员：0.33毫摩尔/升；久坐男性：0.23毫摩尔/升），在长跑运动员的孵育血液中，HDL组分中细胞胆固醇占流失到血浆中的细胞胆固醇总量的比例显著更大（P<0.05）（长跑运动员：89%；久坐男性：64%）。本研究结果表明，在长跑运动员中，高密度脂蛋白浓度升高并非伴随着血浆CETP水平降低，而是与血浆中富含甘油三酯的脂蛋白水平降低相关，这可能促使细胞胆固醇优先分布到“抗动脉粥样硬化”的HDL组分中。