Haberer J P, Audibert G, Saunier C G, Muller C, Laxenaire M C, Hartemann D
Département d'Anesthésiologie, Université de Nancy, France.
Clin Physiol. 1993 Mar;13(2):197-207. doi: 10.1111/j.1475-097x.1993.tb00380.x.
The effect of propofol and thiopentone on cerebral (CBF), myocardial (MBF), muscular, and arterial hepatic blood flow was assessed with radiolabelled microspheres in 12 chronically instrumented dogs, six given propofol and six thiopentone. Tissue blood flows were measured in the awake animal, after 30 min of normoxic anaesthesia (room air), and after 30 min of hypoxic anaesthesia using a mixture of 10% O2 and 3% CO2 in nitrogen. The decrease in CBF from awake to normoxic anaesthesia was similar with propofol and thiopentone (propofol: 77 +/- 8 to 38 +/- 3 ml min-1 100 g-1, P < 0.01; thiopentone: 66 +/- 3 to 33 +/- 2 ml min-1 100 g-1, P < 0.01). During hypoxia, CBF rose moderately in the two groups (respectively +19% and +28%, P < 0.05). The MBF increased in propofol and thiopentone groups after 30 min of anaesthesia with air (propofol: 97 +/- 23 to 137 +/- 15 ml min-1 100 g-1; thiopentone: 82 +/- 7 to 141 +/- 10 ml min-1 100 g-1) and increased still more during hypoxia. The increase in MBF was related to an increase in heart rate and blood pressure. The quadriceps blood flow decreased during anaesthesia in normoxia and in hypoxia. The diaphragmatic blood flow increased with thiopentone under hypoxia. The hepatic arterial blood flow was unchanged. It is concluded that the effects of propofol on regional blood flows are very similar to those of thiopentone.
用放射性微球评估了丙泊酚和硫喷妥钠对12只长期植入仪器的犬的脑（CBF）、心肌（MBF）、肌肉和肝动脉血流的影响，其中6只给予丙泊酚，6只给予硫喷妥钠。在清醒动物、常氧麻醉30分钟（室内空气）后以及使用10%氧气和3%二氧化碳的氮气混合物进行低氧麻醉30分钟后测量组织血流。从清醒到常氧麻醉期间，丙泊酚和硫喷妥钠引起的CBF下降相似（丙泊酚：77±8至38±3 ml·min⁻¹·100g⁻¹，P<0.01；硫喷妥钠：66±3至33±2 ml·min⁻¹·100g⁻¹，P<0.01）。在低氧期间，两组的CBF适度升高（分别升高19%和28%，P<0.05）。在空气麻醉30分钟后，丙泊酚组和硫喷妥钠组的MBF增加（丙泊酚：97±23至137±15 ml·min⁻¹·100g⁻¹；硫喷妥钠：82±7至141±10 ml·min⁻¹·100g⁻¹），在低氧期间增加更多。MBF的增加与心率和血压的增加有关。在常氧和低氧麻醉期间，股四头肌血流减少。在低氧状态下，硫喷妥钠使膈肌血流增加。肝动脉血流未改变。结论是丙泊酚对局部血流的影响与硫喷妥钠非常相似。
